{"id":"W4383955926","doi":"10.1038/s41540-023-00291-8","title":"The Sherpa hypothesis: Phenotype-Preserving Disordered Proteins stabilize the phenotypes of neurons and oligodendrocytes","year":2023,"lang":"en","type":"article","venue":"npj Systems Biology and Applications","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Phenotype; Intrinsically disordered proteins; Biology; Neurodegeneration; Neuroscience; Computational biology; Genetics; Gene; Biophysics; Medicine; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002222474,0.00009815624,0.0001114309,0.00001626807,0.0003886012,0.00002786641,0.0002350444,0.00009460146,0.000001211625],"category_scores_gemma":[0.00006009518,0.00005967439,0.0000286098,0.00009823869,0.0002627094,0.000001949937,0.0001770136,0.00005985946,0.000004500417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002787001,"about_ca_system_score_gemma":0.00002580734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006446269,"about_ca_topic_score_gemma":0.0001317034,"domain_scores_codex":[0.9993094,0.00008536957,0.0001916574,0.0002185017,0.00003553523,0.0001595821],"domain_scores_gemma":[0.9992895,0.0001521639,0.00009979324,0.0003862998,0.00004281106,0.00002949307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006015908,0.00008026396,0.01268655,0.0002462986,0.0002654259,2.392997e-7,0.0004565642,0.0003788719,0.8826579,0.07962497,0.0008581746,0.0226845],"study_design_scores_gemma":[0.002342382,0.000993863,0.1255164,0.0001168815,0.0003305133,0.00006942744,0.01313219,0.02094872,0.03031367,0.05209339,0.7526447,0.001497798],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898984,0.006455133,0.001157679,0.0008184854,0.00006760582,0.0008841316,0.00006920434,0.00002334471,0.0006259495],"genre_scores_gemma":[0.997116,0.001676058,0.00008277858,0.00002308558,0.00008695293,0.0005277743,0.00003251698,0.00001265232,0.0004421618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8523443,"threshold_uncertainty_score":0.2988845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01037140521615868,"score_gpt":0.233105644871493,"score_spread":0.2227342396553343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}