{"id":"W4383998562","doi":"10.1021/acsinfecdis.3c00048","title":"Binding and Sliding Dynamics of the Hepatitis C Virus Polymerase: Hunting the 3′ Terminus","year":2023,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Hepatitis C virus research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; McGill University","funders":"Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies; Natural Sciences and Engineering Research Council of Canada; Consejo Nacional de Ciencia y Tecnología","keywords":"Virology; Dynamics (music); Polymerase; Biology; Virus; Hepatitis C virus; Genetics; Gene; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002224304,0.000133447,0.0002110942,0.0001760556,0.0004522945,0.00006037856,0.000147301,0.000056437,0.00005266042],"category_scores_gemma":[0.001290095,0.00008434703,0.000100434,0.0008545703,0.00020386,0.00009469248,0.0002853994,0.0002196617,0.00003397329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001116594,"about_ca_system_score_gemma":0.0001350404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003076585,"about_ca_topic_score_gemma":0.001991515,"domain_scores_codex":[0.9986892,0.0001196355,0.0002355754,0.000209385,0.0004140906,0.0003320974],"domain_scores_gemma":[0.9988285,0.0004890969,0.00009934526,0.0003928335,0.00007714213,0.0001130848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00001217613,0.00004229924,0.9698834,0.0001085965,0.00006912468,0.00005213383,0.0001611712,0.00000558697,0.002882684,0.0003694727,0.0004363769,0.02597701],"study_design_scores_gemma":[0.0006539938,0.0001172592,0.987453,0.000274256,0.0001862125,0.00006608988,0.0001879962,0.003618218,0.006277573,0.0002655213,0.0007393938,0.0001604296],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963306,0.0002995284,0.00000986917,0.0006365323,0.0002029922,0.0003909826,0.0001517844,0.0001448934,0.001832809],"genre_scores_gemma":[0.9981173,0.001007562,0.000002662548,0.000191444,0.0001219765,0.00004702005,0.00002677414,0.00003412543,0.0004511884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02581658,"threshold_uncertainty_score":0.4650898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01613729792321723,"score_gpt":0.295781003781574,"score_spread":0.2796437058583567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}