{"id":"W4384008721","doi":"10.1002/adma.202300665","title":"Engineered Nanomaterials to Potentiate CRISPR/Cas9 Gene Editing for Cancer Therapy","year":2023,"lang":"en","type":"review","venue":"Advanced Materials","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Guangdong Provincial Pearl River Talents Program; National Key Research and Development Program of China; Youth Innovation Promotion Association of the Chinese Academy of Sciences; China Primary Health Care Foundation; National Natural Science Foundation of China","keywords":"CRISPR; Genome editing; Cas9; Genetic enhancement; Computational biology; Nanomedicine; Viral vector; Biology; Gene; Nanotechnology; Computer science; Materials science; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000279306,0.0006260349,0.0005585263,0.001043721,0.0001447086,0.0004698291,0.0004928593,0.0008186635,0.001919899],"category_scores_gemma":[0.0002546362,0.0002269163,0.0004136275,0.0006741019,0.0001973229,0.0005255693,0.0004658492,0.0009969823,0.001055401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003916727,"about_ca_system_score_gemma":0.0003794347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000432721,"about_ca_topic_score_gemma":0.0008655994,"domain_scores_codex":[0.9998659,0.00002335184,0.00001032132,0.00002102025,0.00006305749,0.00001629315],"domain_scores_gemma":[0.9999373,0.00002644223,0.00001279711,0.000002433621,0.00001623588,0.0000048887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007529875,0.0001743584,0.0001620562,0.01819674,0.000139076,0.0004674811,0.00007524648,0.001214773,0.07222608,0.01178934,0.02504718,0.8704324],"study_design_scores_gemma":[0.00001879247,0.0001724906,0.0004183033,0.001182961,0.0001006558,0.001155813,0.00002710614,0.0004777812,0.02389065,0.001748504,0.9707789,0.00002798761],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001573268,0.9885025,0.002424188,0.0003253599,0.0004240953,0.00003509844,0.0000488517,0.00005698382,0.006609587],"genre_scores_gemma":[0.01214266,0.9799356,0.002477313,0.0004007647,0.0001506181,0.00005688136,0.0001162608,0.00001155053,0.004708244],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001919899,"threshold_uncertainty_score":0.006422698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0374894983717245,"score_gpt":0.4035128304552069,"score_spread":0.3660233320834824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}