{"id":"W4384029517","doi":"10.1093/noajnl/vdad071.001","title":"METABOLOGENOMIC CHARACTERIZATION UNCOVERS HETEROGENEITY AMONG IDH MUTANT GLIOMAS","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Isocitrate dehydrogenase; Glioma; Biology; IDH1; Mutant; Epigenetics; Cancer research; DNA methylation; CDKN2A; Phenotype; Oligodendroglioma; Genetics; Cancer; Astrocytoma; Gene; Enzyme; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001421421,0.0002221694,0.000474158,0.0002592502,0.000144165,0.00001407245,0.0001008388,0.000136464,0.00007626664],"category_scores_gemma":[0.0001529408,0.0001847567,0.0001428312,0.0005635911,0.0001630174,0.0002043048,0.00007111748,0.0001470054,0.0003070852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001213406,"about_ca_system_score_gemma":0.00008160195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001002635,"about_ca_topic_score_gemma":0.00006112776,"domain_scores_codex":[0.998503,0.0001207827,0.0003120418,0.0004832172,0.0001873322,0.0003936744],"domain_scores_gemma":[0.9990717,0.0002392074,0.000180371,0.0002895981,0.00006197704,0.0001572154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001459328,0.0002074992,0.302974,0.00002105865,0.00009227539,0.001213934,0.00006022321,0.00008891951,0.6838093,0.00007496178,0.00009659954,0.01121537],"study_design_scores_gemma":[0.002113376,0.0007334463,0.4942087,0.00001534195,0.0002190152,0.0001819184,0.00005800171,0.0001328974,0.4068538,0.00008088048,0.09524524,0.0001574309],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957553,0.0003829733,0.00002997317,0.001399065,0.00112299,0.000553521,0.00004756432,0.0002671141,0.0004415436],"genre_scores_gemma":[0.9965442,0.001799861,0.0001220542,0.0008926485,0.0001787063,0.0001872408,0.0002118292,0.00003270645,0.00003070623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2769555,"threshold_uncertainty_score":0.7534161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01919857267168329,"score_gpt":0.30035873452983,"score_spread":0.2811601618581467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}