{"id":"W4384029604","doi":"10.1093/noajnl/vdad071.016","title":"ACQUIRED PTEN LOSS MAY MEDIATE DABRAFENIB AND TRAMETINIB RESISTANCE IN BRAF V600E–MUTATED EPITHELIOID GLIOBLASTOMA: A CASE REPORT","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Trametinib; Dabrafenib; PTEN; Temozolomide; Medicine; Cancer research; Vemurafenib; Melanoma; MEK inhibitor; Oncology; PI3K/AKT/mTOR pathway; Glioma; Internal medicine; Biology; MAPK/ERK pathway; Metastatic melanoma; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004028969,0.001389839,0.001035214,0.001901144,0.001710436,0.001896152,0.0009316164,0.003342772,0.002662256],"category_scores_gemma":[0.001646906,0.0009373075,0.0009016602,0.001100688,0.00131548,0.001727937,0.00114982,0.001822867,0.001240678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001110246,"about_ca_system_score_gemma":0.0006030184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001859585,"about_ca_topic_score_gemma":0.002096305,"domain_scores_codex":[0.99943,0.00006411185,0.00006188733,0.00009989171,0.0000815137,0.0002625912],"domain_scores_gemma":[0.9991258,0.0001733453,0.0002632139,0.0001196228,0.00007216898,0.0002458431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00002815164,0.00002123843,0.005039199,0.00002058516,0.000006194471,0.9932275,0.00006150209,0.00002843072,0.0006953522,0.0001017233,0.0001062119,0.0006638439],"study_design_scores_gemma":[0.000007627409,0.00002784363,0.002249973,0.000007385108,0.00001608607,0.9962732,0.00009813586,0.0002432688,0.0006089206,0.000106004,0.0003557971,0.000005703951],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984397,0.00327694,0.002998251,0.001178974,0.000113413,0.0001547795,0.0001537416,0.0001638976,0.00756307],"genre_scores_gemma":[0.9970853,0.0008086428,0.0008593477,0.0002049485,0.0002355505,0.00001594103,0.00005440282,0.00001361198,0.000722182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003342772,"threshold_uncertainty_score":0.008906066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01087095151433648,"score_gpt":0.2837415345649626,"score_spread":0.2728705830506261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}