{"id":"W4384029604","doi":"10.1093/noajnl/vdad071.016","title":"ACQUIRED PTEN LOSS MAY MEDIATE DABRAFENIB AND TRAMETINIB RESISTANCE IN BRAF V600E–MUTATED EPITHELIOID GLIOBLASTOMA: A CASE REPORT","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Trametinib; Dabrafenib; PTEN; Temozolomide; Medicine; Cancer research; Vemurafenib; Melanoma; MEK inhibitor; Oncology; PI3K/AKT/mTOR pathway; Glioma; Internal medicine; Biology; MAPK/ERK pathway; Metastatic melanoma; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005182598,0.0002980076,0.0004247577,0.0001922749,0.000140884,0.00002038398,0.0002178741,0.0003140741,0.00001817829],"category_scores_gemma":[0.000723746,0.0002860455,0.00007919552,0.0004719913,0.0003740641,0.00002285267,0.0001910216,0.000183726,0.00002533818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002291557,"about_ca_system_score_gemma":0.0001520859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001382002,"about_ca_topic_score_gemma":0.001844264,"domain_scores_codex":[0.9975236,0.000288103,0.0005511007,0.0009045572,0.0001602422,0.0005724179],"domain_scores_gemma":[0.9987699,0.0002484299,0.0002618869,0.000474803,0.00006871881,0.0001762757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001438836,0.0001876926,0.008230603,0.0001312553,0.00005642351,0.2247706,0.0004811276,0.00009589134,0.7517732,0.0001325041,0.003282468,0.009419334],"study_design_scores_gemma":[0.00578916,0.002078007,0.006381284,0.00005970535,0.00007326709,0.04825373,0.000678819,0.0001250695,0.3456642,0.001518004,0.5884658,0.0009129275],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941305,0.00202097,0.00005028834,0.0009900057,0.0006536498,0.0003814048,0.00007622746,0.0001013067,0.001595661],"genre_scores_gemma":[0.9963662,0.001277008,0.0005361713,0.0004925127,0.0002397325,0.0001449111,0.0001160317,0.00004834016,0.0007790642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5851833,"threshold_uncertainty_score":0.9999592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01087095151433648,"score_gpt":0.2837415345649626,"score_spread":0.2728705830506261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}