{"id":"W4384038700","doi":"10.1101/2023.07.10.548207","title":"The Hidden Biocatalytic Potential of the Old Yellow Enzyme Family","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Division of Chemistry; Office of Science; Division of Chemical, Bioengineering, Environmental, and Transport Systems; Joint Genome Institute; Emory University; Karl-Franzens-Universität Graz; U.S. Department of Energy; National Science Foundation","keywords":"Synthon; Stereospecificity; Biocatalysis; Enzyme; Protein family; Substrate specificity; Computational biology; Function (biology); Biology; Phylogenetic tree; Sequence (biology); Stereochemistry; Chemistry; Biochemistry; Genetics; Catalysis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004328293,0.0002632822,0.000303462,0.000538677,0.0001853966,0.0009006985,0.0002869597,0.0002361162,0.0004639176],"category_scores_gemma":[0.0005146369,0.0001450909,0.0002496982,0.0005146465,0.0004018877,0.001041012,0.0005834731,0.0004183558,0.0003042029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002558288,"about_ca_system_score_gemma":0.0002049274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004931714,"about_ca_topic_score_gemma":0.0005498981,"domain_scores_codex":[0.9997749,0.00003212451,0.00001772341,0.00006679335,0.00007656085,0.00003199805],"domain_scores_gemma":[0.9997705,0.00005817361,0.0000621154,0.00003473128,0.00003920705,0.00003527593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003512715,0.00009813633,0.03493948,0.0002152536,0.00007955466,0.0007170112,0.0002924706,0.003300317,0.9040692,0.003176114,0.0004147094,0.05234655],"study_design_scores_gemma":[0.00005185437,0.001434705,0.131456,0.0001501621,0.0002425967,0.00586053,0.001434597,0.04632435,0.7459315,0.009883277,0.05712416,0.0001062756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852943,0.004071394,0.008421638,0.0001576903,0.00001014058,0.000007799311,0.0002335281,0.00006804435,0.001735516],"genre_scores_gemma":[0.9903902,0.002070093,0.006146898,0.00005005887,0.00001362677,0.000007258127,0.0005304556,0.0000207897,0.0007706981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009006985,"threshold_uncertainty_score":0.002289057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01106406065118499,"score_gpt":0.2120092354430754,"score_spread":0.2009451747918904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}