{"id":"W4384069971","doi":"10.1101/2023.07.10.548379","title":"<i>Mmp17-</i> deficient mice exhibit heightened goblet cell effector expression in the colon and increased resistance to chronic <i>Trichuris muris</i> infection","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Princess Margaret Cancer Centre; University Health Network","funders":"Norges Forskningsråd; University of Manchester; Medical Research Council; Kreftforeningen","keywords":"Biology; Goblet cell; Cell biology; Immunology; Immune system; Citrobacter rodentium; Intestinal epithelium; Effector; Homeostasis; Trichuris; Inflammation; Extracellular matrix; Epithelium; Helminths; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001839267,0.0008227697,0.0004139466,0.0008992442,0.0001930513,0.0005721546,0.0002755738,0.000787568,0.004059266],"category_scores_gemma":[0.0001432028,0.0003777528,0.0005618439,0.0002137656,0.0006404708,0.0004130697,0.0003032742,0.001611229,0.001038524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000340332,"about_ca_system_score_gemma":0.0001692701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005747527,"about_ca_topic_score_gemma":0.0008500585,"domain_scores_codex":[0.9996564,0.00003916906,0.00005126383,0.00008702849,0.00007445866,0.00009169215],"domain_scores_gemma":[0.999247,0.00004423774,0.0003623698,0.00004724809,0.00003955825,0.0002596294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002297195,0.00003780744,0.0003420694,0.00003508013,0.000006251894,0.00008842018,0.0000114852,0.00002370207,0.9987801,0.00005310792,0.00003565773,0.0003566405],"study_design_scores_gemma":[0.00005737093,0.001027939,0.02194618,0.00003111624,0.00005140132,0.001680857,0.0001948424,0.0007002903,0.9718269,0.0001203881,0.002345939,0.00001675892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938337,0.0006432635,0.002333117,0.0002500361,0.00005369414,0.00003766907,0.001451203,0.0002805807,0.001116838],"genre_scores_gemma":[0.9863288,0.0006995281,0.002860033,0.0001702126,0.00002859086,0.00008441063,0.001294854,0.0001939147,0.008339654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004059266,"threshold_uncertainty_score":0.01357955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01068281750987282,"score_gpt":0.2313385595393411,"score_spread":0.2206557420294683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}