{"id":"W4384069973","doi":"10.1093/noajnl/vdad071.023","title":"HIGH-DIMENSIONAL HISTOPATHOLOGIC EVALUATION OF THE HYPOXIC MICROENVIRONMENT IN GLIOBLASTOMA","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Hypoxia (environmental); Pathology; Biology; Cell type; Angiogenesis; Immunohistochemistry; Cell; Mass cytometry; Tumor microenvironment; Tumour heterogeneity; Cancer research; Phenotype; Medicine; Chemistry; Cancer; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001590966,0.0001512555,0.000167865,0.001083828,0.0001312052,0.0002382085,0.00007852493,0.0001499111,0.0004568972],"category_scores_gemma":[0.0001251437,0.0001201352,0.00009561757,0.0003451685,0.0001459344,0.0001448128,0.0001822576,0.0001372392,0.000116397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001269939,"about_ca_system_score_gemma":0.000103965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000755103,"about_ca_topic_score_gemma":0.001199977,"domain_scores_codex":[0.9999485,0.000007479926,0.000004583232,0.000009885129,0.00001841574,0.00001119961],"domain_scores_gemma":[0.9999152,0.000009165823,0.00002433119,0.000005695249,0.00002589933,0.00001968912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002243399,0.00002160116,0.02087317,0.00006295228,0.00002033042,0.0002491319,0.0000588754,0.0002537241,0.9737873,0.00005677424,0.0000650264,0.004326669],"study_design_scores_gemma":[0.00001013611,0.0003497345,0.5337509,0.00001110839,0.00009443251,0.00322898,0.0004119211,0.006696695,0.4538739,0.0001607623,0.001384539,0.00002693812],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936427,0.0007508934,0.004495759,0.0000223036,0.00000763666,0.00002805757,0.0004604874,0.00007637071,0.000515885],"genre_scores_gemma":[0.9929845,0.000537664,0.005654667,0.00002047398,0.000004793937,0.0000235056,0.0004134827,0.00001083509,0.0003501203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001083828,"threshold_uncertainty_score":0.001528502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02268351073610442,"score_gpt":0.3002158214626405,"score_spread":0.2775323107265361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}