{"id":"W4384069979","doi":"10.1093/noajnl/vdad071.049","title":"TARGETING CANCER STEM CELLS WITH A CDK2 INHIBITOR IN GLIOBLASTOMA","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Cancer research; Stem cell; CDK inhibitor; Cyclin-dependent kinase; Cancer stem cell; Biology; Carcinogenesis; Cancer; Cell cycle; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000121153,0.0001855368,0.0002181291,0.00009792668,0.00007337615,0.00001125894,0.0001822306,0.0001696869,0.00001197122],"category_scores_gemma":[0.00001939756,0.0001639672,0.00004319502,0.0003126177,0.0001329025,0.00001090598,0.0001208854,0.0001821245,0.00002796034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003273764,"about_ca_system_score_gemma":0.0001561401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001249853,"about_ca_topic_score_gemma":0.0008758664,"domain_scores_codex":[0.9986901,0.00009332738,0.0002276154,0.0004823321,0.00009573032,0.0004108585],"domain_scores_gemma":[0.999535,0.00005044762,0.0001111652,0.0001893062,0.00004914397,0.00006489686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002840767,0.00004888219,0.006150391,0.00002947504,0.00001460712,0.00008568657,0.00007428617,0.005219892,0.978007,0.00001220219,0.002604693,0.007468799],"study_design_scores_gemma":[0.0009270154,0.0009819057,0.0002214218,0.00002575554,0.00001166467,0.00001889509,0.0002972134,0.0003449107,0.695856,0.0000161509,0.3010616,0.0002375013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969324,0.001478428,0.0001236652,0.0003199709,0.0005745734,0.0002647333,0.00002545577,0.00004919693,0.0002315746],"genre_scores_gemma":[0.993165,0.004545005,0.000285326,0.0009022459,0.000406095,0.0002013125,0.00002099104,0.00004860419,0.0004254668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2984569,"threshold_uncertainty_score":0.6686389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006734176557242824,"score_gpt":0.2582711645331096,"score_spread":0.2515369879758667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}