{"id":"W4384070050","doi":"10.1093/noajnl/vdad071.040","title":"MOLECULAR PROFILING TO UNDERSTAND TREATMENT RESISTANCE AND RESPONSE IN GLIOBLASTOMA","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Oncology; Glioblastoma; Medicine; Internal medicine; Transcriptome; Gene; Cohort; Gene expression profiling; Cancer research; Gene expression; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001636806,0.0001671917,0.0003341629,0.0003222558,0.00006631035,0.000009957595,0.00004158803,0.00007073625,0.000006609561],"category_scores_gemma":[0.0002792152,0.0001382173,0.00004177168,0.0005649285,0.00007553784,0.00005890823,0.00003652179,0.00008019697,0.00003544516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003253063,"about_ca_system_score_gemma":0.0001087967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004359067,"about_ca_topic_score_gemma":0.0002723721,"domain_scores_codex":[0.9987727,0.0001477347,0.0002041086,0.0004278842,0.0001334591,0.0003140492],"domain_scores_gemma":[0.9989216,0.000647665,0.00004590303,0.0002052936,0.00002808222,0.0001514045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03704087,0.001361728,0.08326742,0.0001408571,0.0001455344,0.0368866,0.003006233,0.001576454,0.8057156,0.001888701,0.0007950148,0.02817499],"study_design_scores_gemma":[0.01829087,0.02492345,0.09667078,0.0003189486,0.0002242117,0.0003864772,0.004779017,0.0002452544,0.7048053,0.002023076,0.1467548,0.0005778124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871508,0.001829749,0.00001248077,0.009542926,0.0001243562,0.0007272046,0.000009526782,0.00009267746,0.0005102467],"genre_scores_gemma":[0.9973559,0.0008389191,0.0007519913,0.0007374383,0.00002311121,0.0001893053,0.000003269937,0.0000215623,0.00007852829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1459597,"threshold_uncertainty_score":0.5636337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02083334881045462,"score_gpt":0.3271625864875808,"score_spread":0.3063292376771262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}