{"id":"W4384070157","doi":"10.1093/noajnl/vdad071.010","title":"SONIC HEDGEHOG (SHH) PROMOTES BLOOD-BRAIN BARRIER (BBB) INTEGRITY IN DIFFUSE MIDLINE GLIOMA OF THE PONS","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Sonic hedgehog; GLI1; Blood–brain barrier; Abcg2; Cancer research; Hedgehog signaling pathway; Tight junction; Transcytosis; ATP-binding cassette transporter; Smoothened; Cell biology; Biology; Chemistry; Medicine; Signal transduction; Internal medicine; Transporter; Endocrinology; Central nervous system; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005188127,0.0002073583,0.0001644371,0.0001351215,0.00008710697,0.0001362649,0.00008838109,0.000128417,0.0007365029],"category_scores_gemma":[0.00005831645,0.00006578524,0.0001254247,0.0000878865,0.0001513786,0.0001146734,0.0001667669,0.0003977912,0.0001161184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000202157,"about_ca_system_score_gemma":0.0001624739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001280401,"about_ca_topic_score_gemma":0.001600541,"domain_scores_codex":[0.9999555,0.000006778162,0.000002686429,0.00000608408,0.00001338123,0.00001549938],"domain_scores_gemma":[0.9999741,0.000003381571,0.000006422734,0.000002086376,0.000003747359,0.00001022689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00015349,0.00003830452,0.0003533649,0.00005361612,0.000005417608,0.0001855993,0.00001529991,0.0000426058,0.9972385,0.00006766042,0.00005681475,0.001789214],"study_design_scores_gemma":[0.00004262391,0.001528419,0.01852092,0.000006942268,0.00002491326,0.0009841344,0.00009946346,0.001341715,0.9751838,0.00007899755,0.00218324,0.000004914774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979547,0.000705309,0.0007237557,0.00004644346,0.00001358241,0.00001168722,0.00006507173,0.00003211766,0.0004472684],"genre_scores_gemma":[0.9983866,0.0004108163,0.0004125229,0.00001728867,0.000004531283,0.000007852744,0.00008717653,0.00000282958,0.0006703604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001280401,"threshold_uncertainty_score":0.002545953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01831818105683399,"score_gpt":0.299253236923172,"score_spread":0.280935055866338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}