{"id":"W4384070157","doi":"10.1093/noajnl/vdad071.010","title":"SONIC HEDGEHOG (SHH) PROMOTES BLOOD-BRAIN BARRIER (BBB) INTEGRITY IN DIFFUSE MIDLINE GLIOMA OF THE PONS","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Sonic hedgehog; GLI1; Blood–brain barrier; Abcg2; Cancer research; Hedgehog signaling pathway; Tight junction; Transcytosis; ATP-binding cassette transporter; Smoothened; Cell biology; Biology; Chemistry; Medicine; Signal transduction; Internal medicine; Transporter; Endocrinology; Central nervous system; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004863159,0.0002516858,0.0003857465,0.0001279709,0.0001429612,0.000008113936,0.0005118805,0.0002600616,0.00001165114],"category_scores_gemma":[0.002931709,0.0001902568,0.0001604219,0.0006008719,0.0005445873,0.000009424059,0.0004580517,0.0004017521,0.00001222902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000207449,"about_ca_system_score_gemma":0.0002205673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001559312,"about_ca_topic_score_gemma":0.0007330691,"domain_scores_codex":[0.9979578,0.000423079,0.0004368403,0.0005477821,0.0001705747,0.0004639479],"domain_scores_gemma":[0.9987035,0.0004212399,0.0001937616,0.0005084552,0.0001021005,0.00007087845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009059791,0.0002803027,0.02233228,0.00005034964,0.00004767242,0.00005844615,0.0002715981,0.000112893,0.9747796,0.00007713968,0.0006327531,0.001266375],"study_design_scores_gemma":[0.002049536,0.0009366818,0.01735905,0.00004931838,0.00004503855,0.00005696824,0.0003992103,0.00009747449,0.9262269,0.0005672902,0.05193669,0.000275801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939725,0.0019752,0.00002533257,0.002606574,0.0006023973,0.0003859473,0.00005967878,0.00004776979,0.0003245953],"genre_scores_gemma":[0.9981415,0.0004394125,0.0002040643,0.0006330798,0.000187782,0.00009142478,0.00002240456,0.00003328548,0.0002470701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05130394,"threshold_uncertainty_score":0.7758448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01831818105683399,"score_gpt":0.299253236923172,"score_spread":0.280935055866338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}