{"id":"W4384070182","doi":"10.1093/noajnl/vdad071.006","title":"COMPREHENSIVE MULTIPLATFORM ANALYSIS OF CDKN2A ALTERATIONS IN MENINGIOMAS","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Meningioma and schwannoma management","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"CDKN2A; DNA methylation; Cancer research; Biology; Transcriptome; Biomarker; Meningioma; Methylation; Gene; Copy-number variation; Gene expression; Oncology; Genetics; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002631008,0.0002313352,0.0001834334,0.001146904,0.00020233,0.0003050696,0.0001323065,0.0001120788,0.0006159968],"category_scores_gemma":[0.0003101941,0.0001180951,0.0001972066,0.0006021535,0.0001419892,0.0001043632,0.0002877912,0.0001817585,0.0001756432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000333805,"about_ca_system_score_gemma":0.0001979806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003393921,"about_ca_topic_score_gemma":0.005313299,"domain_scores_codex":[0.9998919,0.000008245945,0.00001006195,0.00003800746,0.00003482934,0.00001706946],"domain_scores_gemma":[0.9998447,0.00001995973,0.00004806195,0.00002587104,0.00002986888,0.00003148851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007176292,0.00004263599,0.1793937,0.00008930673,0.0001860851,0.0003586981,0.0001195024,0.0008456558,0.803683,0.0001129377,0.0002604811,0.01419054],"study_design_scores_gemma":[0.00001025793,0.0001163124,0.8942909,0.000005777729,0.00008634185,0.001172241,0.0000833942,0.0018421,0.1006278,0.0001350565,0.001619826,0.000009979432],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996991,0.0002584102,0.001068404,0.00001209971,0.000001701393,0.0000113062,0.001371305,0.00003438447,0.0002513884],"genre_scores_gemma":[0.9947006,0.0001770256,0.002351587,0.000008886643,0.000002603133,0.0000166371,0.002380205,0.00001196254,0.0003504995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003393921,"threshold_uncertainty_score":0.006748319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.045073908589617,"score_gpt":0.3553010656809361,"score_spread":0.3102271570913191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}