{"id":"W4384070320","doi":"10.1093/noajnl/vdad071.037","title":"SHH PATHWAY ACTIVATION IN DEDIFFERENTIATION DURING TUMOR PROGRESSION IN MPNST","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Cancer research; Biology; Neural crest; Wnt signaling pathway; Transcription factor; Cell biology; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014646,0.0001056948,0.0001177673,0.0001727231,0.00005415759,0.000008900306,0.00009604109,0.0001098046,0.0000101841],"category_scores_gemma":[0.0002922831,0.0001019214,0.00002745882,0.0003023513,0.0000406806,0.00002474505,0.00007127855,0.0001367133,0.00001358451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000440772,"about_ca_system_score_gemma":0.00006103227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003000624,"about_ca_topic_score_gemma":0.0001269388,"domain_scores_codex":[0.9990034,0.0001258645,0.0002273612,0.0003109033,0.00009920037,0.0002332851],"domain_scores_gemma":[0.9996765,0.0000308758,0.0001097756,0.0001251721,0.00002341962,0.0000342471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000121012,0.00006367984,0.03834022,0.00001869163,0.000001582234,0.00001264392,0.000043212,0.0001347677,0.9477108,0.00002914793,0.00008141773,0.01344287],"study_design_scores_gemma":[0.0008848674,0.0001973824,0.08560556,0.00003208796,9.816983e-7,0.000004246781,0.00008088004,0.0001267386,0.8968124,0.0001299517,0.016015,0.0001099165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983743,0.0001321229,0.00005960726,0.0003843206,0.0003340165,0.000287549,0.000002083978,0.00003636584,0.0003895863],"genre_scores_gemma":[0.9990399,0.000213465,0.0001204818,0.0001617454,0.0001502849,0.0001412789,0.0001047457,0.00001298493,0.00005508721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05089836,"threshold_uncertainty_score":0.4156234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009554455636887315,"score_gpt":0.2891293697462169,"score_spread":0.2795749141093296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}