{"id":"W4384070361","doi":"10.1093/noajnl/vdad071.005","title":"SHH PATHWAY ACTIVATION DRIVES MALIGNANT TRANSFORMATION IN A SUBSET OF MPNSTS AND IS A POTENTIAL THERAPEUTIC TARGET","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Brain Tumor Funders' Collaborative","keywords":"Cancer research; Wnt signaling pathway; PTCH1; Biology; Malignant transformation; Transcriptome; Epigenomics; Hedgehog signaling pathway; DNA methylation; Exome sequencing; Signal transduction; Cell biology; Genetics; Gene expression; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009589965,0.0001141014,0.0001423631,0.0002158977,0.00008778005,0.0002101765,0.00008205106,0.0001006887,0.001243137],"category_scores_gemma":[0.0001824504,0.00007559523,0.00009627871,0.0001256605,0.0001101444,0.0001066836,0.0001338628,0.0002733128,0.0001682618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001844,"about_ca_system_score_gemma":0.0001179448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000431835,"about_ca_topic_score_gemma":0.0006747617,"domain_scores_codex":[0.9999405,0.000009470147,0.000002829328,0.00001103896,0.00002382978,0.00001225568],"domain_scores_gemma":[0.9999142,0.00001547934,0.0000266815,0.000007637121,0.0000108039,0.00002518457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006317612,0.00005569485,0.0367682,0.00005989415,0.00003867768,0.000394886,0.00004761072,0.0002667645,0.9387478,0.0001562862,0.0005196044,0.0223128],"study_design_scores_gemma":[0.00008094566,0.001374314,0.6358919,0.00002016144,0.0001011322,0.005410012,0.0002563421,0.004378238,0.3441863,0.0007154522,0.007572401,0.00001278511],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973757,0.0008255604,0.0005965305,0.00009946171,0.000006545363,0.00001283151,0.0001844707,0.0000529438,0.0008458992],"genre_scores_gemma":[0.9987881,0.0002863547,0.0002519828,0.00001953447,0.000005777396,0.000008338275,0.000190133,0.000005074136,0.0004446762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001243137,"threshold_uncertainty_score":0.004158735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01825083190189815,"score_gpt":0.2895285685455639,"score_spread":0.2712777366436657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}