{"id":"W4384070361","doi":"10.1093/noajnl/vdad071.005","title":"SHH PATHWAY ACTIVATION DRIVES MALIGNANT TRANSFORMATION IN A SUBSET OF MPNSTS AND IS A POTENTIAL THERAPEUTIC TARGET","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Brain Tumor Funders' Collaborative","keywords":"Cancer research; Wnt signaling pathway; PTCH1; Biology; Malignant transformation; Transcriptome; Epigenomics; Hedgehog signaling pathway; DNA methylation; Exome sequencing; Signal transduction; Cell biology; Genetics; Gene expression; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001343236,0.0001220655,0.0003168022,0.0002336689,0.00005010705,0.000006771818,0.00004799019,0.00008672235,0.00003040153],"category_scores_gemma":[0.00004716506,0.0001013421,0.00005305515,0.0003296617,0.0001095465,0.0002854973,0.00001715145,0.0001327737,0.000005873104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000170683,"about_ca_system_score_gemma":0.00006932839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000052972,"about_ca_topic_score_gemma":0.000006530253,"domain_scores_codex":[0.9989719,0.0001098607,0.0003282305,0.0002327666,0.000160981,0.0001962966],"domain_scores_gemma":[0.9994864,0.0001907609,0.0001218966,0.0001128426,0.00003874069,0.00004938061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005269335,0.000135705,0.01704474,0.0001751426,0.00001531995,0.0001700693,0.001539155,0.00005403517,0.9556602,0.0003502776,0.00008175894,0.02424671],"study_design_scores_gemma":[0.003299573,0.00232435,0.2115768,0.0001376355,0.00004649549,0.0003377372,0.001122736,0.002038164,0.7594301,0.001809578,0.01768366,0.0001932368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959497,0.0004380109,0.0001217006,0.002596211,0.00015461,0.000373248,0.00002280905,0.00005380043,0.0002898629],"genre_scores_gemma":[0.9982195,0.0008311596,0.0001703485,0.0006521948,0.00003260807,0.00003784323,0.00002799454,0.00001342217,0.00001492277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1962301,"threshold_uncertainty_score":0.4132613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01825083190189815,"score_gpt":0.2895285685455639,"score_spread":0.2712777366436657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}