{"id":"W4384070387","doi":"10.1093/noajnl/vdad071.004","title":"GENETIC SCREENING REVEALS DEPENDENCY ON FEN1 TO RESIST TEMOZOLOMIDE IN TREATMENT-RESISTANT GLIOBLASTOMA STEM CELLS","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Brain Tumor Funders' Collaborative","keywords":"Temozolomide; Cancer research; CRISPR; Methyltransferase; Glioblastoma; Stem cell; DNA repair; Biology; Chemoradiotherapy; Medicine; Oncology; Chemotherapy; Gene; Genetics; Methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001452987,0.0003653311,0.0007598785,0.0006323355,0.0001571826,0.00002054286,0.000159897,0.0001543056,0.00004978426],"category_scores_gemma":[0.000106716,0.0002971737,0.0001482085,0.000897723,0.00006995127,0.00007916274,0.00007221507,0.000185459,0.0005853286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004128774,"about_ca_system_score_gemma":0.0001017801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005024133,"about_ca_topic_score_gemma":0.00120837,"domain_scores_codex":[0.9974049,0.0002308571,0.0005460432,0.0008194002,0.0003218437,0.0006769969],"domain_scores_gemma":[0.9978974,0.001094892,0.0001567191,0.0004983079,0.00005242394,0.0003002367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005963584,0.002087581,0.2509368,0.0001089965,0.0001912965,0.02748886,0.0005070295,0.00396841,0.4369145,0.0001627254,0.004855343,0.2668149],"study_design_scores_gemma":[0.01429295,0.03278524,0.5020853,0.0005460497,0.0004106424,0.0003013052,0.0009721965,0.0001660308,0.3022169,0.0003860098,0.1450844,0.0007528866],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928411,0.001172698,0.0000073459,0.003072056,0.0004678479,0.001235618,0.00003795107,0.0002037435,0.0009616211],"genre_scores_gemma":[0.9953336,0.001146151,0.001002295,0.001252471,0.0001563063,0.0005791025,0.000006846131,0.00005823142,0.0004650536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.266062,"threshold_uncertainty_score":0.999948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02635917752647555,"score_gpt":0.3139758920006717,"score_spread":0.2876167144741962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}