{"id":"W4384070387","doi":"10.1093/noajnl/vdad071.004","title":"GENETIC SCREENING REVEALS DEPENDENCY ON FEN1 TO RESIST TEMOZOLOMIDE IN TREATMENT-RESISTANT GLIOBLASTOMA STEM CELLS","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Brain Tumor Funders' Collaborative","keywords":"Temozolomide; Cancer research; CRISPR; Methyltransferase; Glioblastoma; Stem cell; DNA repair; Biology; Chemoradiotherapy; Medicine; Oncology; Chemotherapy; Gene; Genetics; Methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001707737,0.0003347186,0.000389213,0.0003497981,0.0001726371,0.0002877918,0.0003332486,0.000316411,0.001450536],"category_scores_gemma":[0.0001391412,0.0001183563,0.0002922169,0.0001912078,0.0002029723,0.00009540973,0.0002256899,0.0003979685,0.0004893881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000399129,"about_ca_system_score_gemma":0.0002654428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001778471,"about_ca_topic_score_gemma":0.002817886,"domain_scores_codex":[0.9998091,0.00001931347,0.00001968354,0.00004187809,0.00007908829,0.00003090224],"domain_scores_gemma":[0.9998876,0.00002537815,0.00003483623,0.00001459244,0.00001544446,0.00002215505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000478629,0.00002300114,0.0003045569,0.00002323136,0.000005720885,0.0000533603,0.00001112599,0.0002048434,0.9975562,0.00007817864,0.00007357909,0.001618465],"study_design_scores_gemma":[0.000007178909,0.0001660078,0.003955746,0.000004578754,0.00001505703,0.0002381081,0.00002861531,0.00195091,0.9917157,0.00002272868,0.001888041,0.000007262396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901697,0.0006705617,0.005225792,0.0001321634,0.00002569675,0.00006240325,0.001777493,0.0002576009,0.001678488],"genre_scores_gemma":[0.992209,0.0003162011,0.003168679,0.00005767765,0.000002578411,0.00004074133,0.0016003,0.00004479457,0.002560057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001778471,"threshold_uncertainty_score":0.004852533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02635917752647555,"score_gpt":0.3139758920006717,"score_spread":0.2876167144741962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}