{"id":"W4384070397","doi":"10.1093/noajnl/vdad071.024","title":"AUTOLOGOUS PATIENT-DERIVED CAR-TS SHOW FUNCTIONAL DEFICITS AGAINST HUMAN GLIOBLASTOMA","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Chimeric antigen receptor; Medicine; Immunotherapy; Clinical trial; Immune system; Antigen; Glioblastoma; Brain tumor; Cell therapy; Cancer research; Oncology; Immunology; Internal medicine; Cell; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001416287,0.0002579036,0.0002539805,0.0001209853,0.00008204144,0.0002329519,0.0001240897,0.0002130795,0.002592126],"category_scores_gemma":[0.0001045008,0.00006274789,0.000195374,0.00009928765,0.0001222436,0.000118273,0.0001333845,0.0006403814,0.0005350416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001359069,"about_ca_system_score_gemma":0.0001635849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000608891,"about_ca_topic_score_gemma":0.0004779896,"domain_scores_codex":[0.9998837,0.00001559567,0.00001422899,0.00002625863,0.00002872358,0.00003154634],"domain_scores_gemma":[0.9999357,0.00001314676,0.000009901854,0.0000120358,0.00001283758,0.00001626764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004661954,0.0002776841,0.0004717785,0.00007794407,0.00002098409,0.00007888941,0.00005081577,0.0002868892,0.9929255,0.0001517356,0.0003902171,0.004801278],"study_design_scores_gemma":[0.00005273702,0.00355897,0.005903034,0.00001187049,0.00006603346,0.0005855853,0.00006497419,0.001677957,0.9837082,0.00009764401,0.004266505,0.000006513887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967293,0.0004547467,0.001245507,0.00005418109,0.00002819518,0.00002195738,0.000480472,0.00006669773,0.0009190582],"genre_scores_gemma":[0.9968206,0.0002707618,0.0004434821,0.00004428074,0.000005160516,0.00002609907,0.0009701406,0.0000127334,0.001406887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002592126,"threshold_uncertainty_score":0.008671522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03225344404747963,"score_gpt":0.3269874848245949,"score_spread":0.2947340407771153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}