{"id":"W4384070508","doi":"10.1093/noajnl/vdad071.044","title":"REPURPOSING OF FDA APPROVED COMPOUNDS TO INHIBIT OSM/OSMR SIGNALING IN GLIOBLASTOMA","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Repurposing; Pharmacology; Drug repositioning; Signal transduction; Potency; Drug; Chemistry; Medicine; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000388345,0.0001854653,0.0003342654,0.0002030346,0.00007928514,0.00001315501,0.0002367142,0.0001818051,0.00002149901],"category_scores_gemma":[0.0002596087,0.0001902515,0.00008935407,0.0004948705,0.00007637705,0.00001210968,0.0001824089,0.0001631137,0.00001493095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002613535,"about_ca_system_score_gemma":0.00007865707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009571807,"about_ca_topic_score_gemma":0.0001006175,"domain_scores_codex":[0.9983687,0.0001463141,0.0004357119,0.0005147389,0.0001524866,0.0003820866],"domain_scores_gemma":[0.9992852,0.0001298213,0.0001656546,0.0002510415,0.00007798553,0.00009026703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002712827,0.00005187617,0.0008137807,0.0000285385,0.00001137283,0.0000300126,0.0001701936,0.005144588,0.9841678,0.00008327479,0.0003656947,0.008861645],"study_design_scores_gemma":[0.0005516989,0.001290107,0.00006672608,0.0000365397,0.000007189281,0.00001726386,0.0003433958,0.0001989565,0.9192962,0.0003396104,0.07767383,0.0001784956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967579,0.0006417263,0.0008980988,0.0002009239,0.0005245333,0.0002974678,0.000008295567,0.00004176717,0.0006293422],"genre_scores_gemma":[0.99671,0.0002533785,0.002136104,0.0005348458,0.0001810278,0.00005583568,0.00001948556,0.0000330854,0.00007624162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07730813,"threshold_uncertainty_score":0.7758232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228848211131334,"score_gpt":0.2833555459302863,"score_spread":0.271067063818973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}