{"id":"W4384070508","doi":"10.1093/noajnl/vdad071.044","title":"REPURPOSING OF FDA APPROVED COMPOUNDS TO INHIBIT OSM/OSMR SIGNALING IN GLIOBLASTOMA","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Repurposing; Pharmacology; Drug repositioning; Signal transduction; Potency; Drug; Chemistry; Medicine; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002273531,0.0004794284,0.0006690941,0.0008137635,0.0002214409,0.0003910351,0.0002630509,0.0002589197,0.004034336],"category_scores_gemma":[0.0002566428,0.0001555768,0.0004883154,0.0004275744,0.0001703087,0.0002124236,0.0002757348,0.00045021,0.0007871673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002960966,"about_ca_system_score_gemma":0.0003512969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007722051,"about_ca_topic_score_gemma":0.002795877,"domain_scores_codex":[0.9998672,0.00002606566,0.00001320908,0.0000161273,0.00004051669,0.0000368698],"domain_scores_gemma":[0.9998726,0.00001948717,0.00002913048,0.00001017724,0.00003933034,0.00002937044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00136597,0.0008428881,0.002723985,0.0007443592,0.0001448024,0.0009809457,0.00008830818,0.001828074,0.9148806,0.0003663689,0.002839626,0.07319402],"study_design_scores_gemma":[0.0007590871,0.02605481,0.01961018,0.0001743958,0.0005315742,0.00249989,0.0002082791,0.004136345,0.9113457,0.0002753813,0.03433069,0.00007370552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9693741,0.01490331,0.002743257,0.0005855486,0.0001451287,0.0006250574,0.003332376,0.0002870432,0.008004169],"genre_scores_gemma":[0.9764968,0.008589192,0.00393377,0.0005072028,0.00007520629,0.0001537379,0.003443279,0.00005059528,0.006750259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004034336,"threshold_uncertainty_score":0.01349622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228848211131334,"score_gpt":0.2833555459302863,"score_spread":0.271067063818973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}