{"id":"W4384071654","doi":"10.7554/elife.89331.1","title":"A PI(3,4,5)P3-dependent allosteric switch controls antigenic variation in trypanosomes","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; Alliance de recherche numérique du Canada; Islamic Development Bank; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Biology; Gene silencing; Repressor; Antigenic variation; Cell biology; Rap1; Genetics; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006298187,0.0001308767,0.00008493487,0.000103622,0.0001379417,0.0002989056,0.000179906,0.0001468187,0.001354289],"category_scores_gemma":[0.0001248306,0.00007790943,0.00009398264,0.00007632603,0.0002544175,0.0001631117,0.0002066809,0.0002222754,0.0003055149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003569531,"about_ca_system_score_gemma":0.0001340587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006148515,"about_ca_topic_score_gemma":0.000701541,"domain_scores_codex":[0.9999503,0.000008570872,0.000002400446,0.00001465054,0.00000981026,0.00001435025],"domain_scores_gemma":[0.9999431,0.00001178548,0.00001747497,0.000005200939,0.000006975446,0.00001528959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001000203,0.00001279239,0.0004271062,0.00001575871,0.00000201662,0.00004320792,0.0000121624,0.00008988951,0.9977733,0.00034995,0.00005428514,0.001119527],"study_design_scores_gemma":[0.00006490202,0.0002131451,0.0360218,0.000009139408,0.00001528139,0.0003581656,0.00008894283,0.01160826,0.9472379,0.001248814,0.003119027,0.0000147507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946578,0.0004783964,0.002455235,0.00008513268,0.00001404327,0.000008003995,0.0001065191,0.0001125426,0.002082364],"genre_scores_gemma":[0.9990262,0.0001062045,0.0003128347,0.00001727014,0.000002500555,0.000004926564,0.00004626219,0.000006951558,0.0004769051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001354289,"threshold_uncertainty_score":0.004530489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0661069617792726,"score_gpt":0.351201092745158,"score_spread":0.2850941309658854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}