{"id":"W4384081649","doi":"10.17952/36eps.2022.275","title":"Epitope Determination of DNA and RNA Aptamers as Antibody Alternatives by Affinity-Mass Spectrometry Open New Perspectives for Peptide Biomarkers and Molecular Diagnostics","year":2022,"lang":"en","type":"article","venue":"","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"Aptamer; Epitope; Mass spectrometry; Computational biology; DNA; RNA; Chemistry; Peptide; Antibody; Molecular biology; Chromatography; Biology; Biochemistry; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008293556,0.0006270584,0.0004960525,0.0004013247,0.0001598026,0.000857296,0.0007709931,0.001053001,0.001499234],"category_scores_gemma":[0.0006770587,0.0002299163,0.0002514367,0.0002901376,0.0005152414,0.001111136,0.0004213033,0.001228736,0.0008491781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003172776,"about_ca_system_score_gemma":0.0002155429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001750675,"about_ca_topic_score_gemma":0.0003401588,"domain_scores_codex":[0.9996315,0.00009458174,0.00001322587,0.00009728971,0.0001139529,0.00004942336],"domain_scores_gemma":[0.9996253,0.000164074,0.00007207972,0.00003187197,0.0000589839,0.00004766241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001013487,0.00004639467,0.0003445046,0.0001121475,0.00001257886,0.00005491501,0.00002032708,0.0001906386,0.9800066,0.003523171,0.0001769631,0.01541027],"study_design_scores_gemma":[0.00002176488,0.0002148555,0.0007700606,0.00001211347,0.0000224211,0.0002924995,0.00003661554,0.003638109,0.9840885,0.003856341,0.007029144,0.0000175022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4506928,0.04032313,0.4927124,0.002769255,0.0005634805,0.000152161,0.0009106955,0.0009694339,0.01090662],"genre_scores_gemma":[0.8408239,0.009351601,0.1401742,0.001380375,0.0002365613,0.0001099986,0.0006492505,0.0001135287,0.007160602],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001499234,"threshold_uncertainty_score":0.005015433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009592291787264796,"score_gpt":0.2845325020369752,"score_spread":0.2749402102497104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}