{"id":"W4384106248","doi":"10.1210/endrev/bnad024","title":"Biomarkers to Guide Medical Therapy in Primary Aldosteronism","year":2023,"lang":"en","type":"article","venue":"Endocrine Reviews","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; National Institutes of Health; Institute of Nutrition, Metabolism and Diabetes; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada; Duke University; American Heart Association","keywords":"Primary aldosteronism; Medicine; Hypokalemia; Adrenalectomy; Blood pressure; Adverse effect; Aldosterone; Endocrine system; Internal medicine; Urology; Hyperaldosteronism; Intensive care medicine; Endocrinology; Bioinformatics; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006647432,0.0001252184,0.0004711807,0.0002303936,0.00002314159,0.000006516457,0.00009065537,0.00003634282,0.0006204698],"category_scores_gemma":[0.0004868817,0.00008528648,0.0001107106,0.0006112946,0.00002103935,0.00003331358,0.00006366052,0.0001160203,0.00181423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008127772,"about_ca_system_score_gemma":0.0001094631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005316981,"about_ca_topic_score_gemma":0.00002231001,"domain_scores_codex":[0.9985532,0.00008469538,0.000478475,0.0002269794,0.0004029106,0.0002538053],"domain_scores_gemma":[0.9993371,0.00005606194,0.00003776263,0.0002783365,0.00003106322,0.0002597162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007138609,0.00004490376,0.001329415,0.00005463222,0.0000137549,0.0004597628,0.00005336601,2.758254e-7,0.004715722,0.00004905102,0.1488479,0.8443599],"study_design_scores_gemma":[0.00112533,0.0001173062,0.07124411,0.0003035432,0.0000065726,0.0001545173,0.00001019825,0.0000768848,0.0002162633,0.00001169084,0.9266557,0.00007789341],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.5152849,0.07824817,0.0001682939,0.3175576,0.0008505094,0.005626755,0.000005888263,0.0005721428,0.08168574],"genre_scores_gemma":[0.1389998,0.6366547,0.007965137,0.1458637,0.001664573,0.0008566341,0.0005300682,0.0002299096,0.0672355],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.844282,"threshold_uncertainty_score":0.998963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06326111674677817,"score_gpt":0.3712721170211457,"score_spread":0.3080110002743675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}