{"id":"W4384108748","doi":"10.1093/noajnl/vdad071.034","title":"JAK/STAT PATHWAY COOPERATES WITH CIC FUSIONS TO DRIVE CIC-REARRANGED SARCOMAS","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"STAT1; Cancer research; Transcription factor; Fusion protein; JAK-STAT signaling pathway; Effector; STAT protein; Carcinogenesis; Biology; PIM1; ETS transcription factor family; STAT3; Repressor; Signal transduction; Gene; Cell biology; Phosphorylation; Receptor tyrosine kinase; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001311779,0.0002170008,0.0001930657,0.0002009528,0.0001441461,0.0002026004,0.0001208374,0.0002393656,0.001345609],"category_scores_gemma":[0.00008619368,0.0001057232,0.0002027407,0.0001283215,0.0001594346,0.00008490442,0.0001497671,0.0004418213,0.0003147853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002910791,"about_ca_system_score_gemma":0.0001552328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000474924,"about_ca_topic_score_gemma":0.0007715398,"domain_scores_codex":[0.9998393,0.00002536279,0.00001933167,0.00002373929,0.00004875885,0.00004347742],"domain_scores_gemma":[0.9998851,0.00002850971,0.00002551001,0.00001919473,0.000007461655,0.00003422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007857839,0.00005567474,0.0004724379,0.00001898671,0.000004302815,0.0001271584,0.000009459774,0.00008602678,0.9984395,0.000083626,0.00006175475,0.0005625249],"study_design_scores_gemma":[0.00003090845,0.000463606,0.00793955,0.000003050331,0.00001468701,0.001149544,0.00002688766,0.002163114,0.9864971,0.00003834481,0.001670403,0.000002780294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981451,0.0003180461,0.0004859312,0.00004638751,0.00001420427,0.00002787776,0.0002531618,0.00004921705,0.0006601079],"genre_scores_gemma":[0.9984838,0.00008394822,0.0004010356,0.00001692772,0.000002878342,0.0000149456,0.0003548605,0.000004081721,0.0006375448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001345609,"threshold_uncertainty_score":0.004501522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0223342403304206,"score_gpt":0.3141566071547616,"score_spread":0.291822366824341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}