{"id":"W4384108748","doi":"10.1093/noajnl/vdad071.034","title":"JAK/STAT PATHWAY COOPERATES WITH CIC FUSIONS TO DRIVE CIC-REARRANGED SARCOMAS","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"STAT1; Cancer research; Transcription factor; Fusion protein; JAK-STAT signaling pathway; Effector; STAT protein; Carcinogenesis; Biology; PIM1; ETS transcription factor family; STAT3; Repressor; Signal transduction; Gene; Cell biology; Phosphorylation; Receptor tyrosine kinase; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000120446,0.000290882,0.0005671891,0.0002469464,0.0002706614,0.00001951828,0.000141281,0.0001069486,0.0002413817],"category_scores_gemma":[0.0002585203,0.0002033301,0.00008967581,0.0008645994,0.0001669487,0.0001174174,0.00009859663,0.000257824,0.0008213439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001062154,"about_ca_system_score_gemma":0.0002140898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002491935,"about_ca_topic_score_gemma":0.0004652428,"domain_scores_codex":[0.9981543,0.0001353573,0.0002780965,0.0005998795,0.0002800727,0.0005523149],"domain_scores_gemma":[0.9980692,0.0009636816,0.00008488311,0.0004027142,0.0001527396,0.0003267951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002191538,0.00260789,0.5379486,0.0001143141,0.0004030238,0.0145721,0.002879146,0.000729031,0.1757788,0.00109558,0.02144423,0.2402358],"study_design_scores_gemma":[0.005518253,0.006513114,0.1840354,0.0001582749,0.0002426589,0.000511316,0.001442293,0.00007097382,0.03528883,0.0001809282,0.7656173,0.0004206637],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758193,0.00196998,0.00002163398,0.01517098,0.0005012743,0.001081359,0.00004692038,0.0003728649,0.005015715],"genre_scores_gemma":[0.99019,0.001612483,0.001215859,0.005503653,0.0001926008,0.0006498646,0.00007339071,0.00005864527,0.0005034528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7441731,"threshold_uncertainty_score":0.9999566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0223342403304206,"score_gpt":0.3141566071547616,"score_spread":0.291822366824341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}