{"id":"W4384120297","doi":"10.1158/1078-0432.ccr-22-3273","title":"Dual Role of CXCL8 in Maintaining the Mesenchymal State of Glioblastoma Stem Cells and M2-Like Tumor-Associated Macrophages","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Microsemi (Canada)","funders":"National Natural Science Foundation of China","keywords":"Mesenchymal stem cell; Cancer research; Paracrine signalling; Biology; Tumor microenvironment; PI3K/AKT/mTOR pathway; Tumor progression; Reprogramming; Stem cell; STAT3; Signal transduction; Cell; Cell biology; Cancer; Receptor; Genetics; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001258742,0.0002649106,0.0001467441,0.000246203,0.0001516427,0.0002207113,0.00009484016,0.000115988,0.0008806834],"category_scores_gemma":[0.0000590005,0.00004839163,0.0001368456,0.000129325,0.0002138937,0.0001537888,0.0001756248,0.0003026051,0.0001354187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002504053,"about_ca_system_score_gemma":0.0003362021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003777917,"about_ca_topic_score_gemma":0.0007314842,"domain_scores_codex":[0.9999033,0.00001549666,0.000007886306,0.00001812974,0.00002253347,0.00003260585],"domain_scores_gemma":[0.9999307,0.000004142071,0.00002443644,0.000004623693,0.00001191272,0.00002419094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002320018,0.00003571375,0.003695066,0.000126661,0.000007108135,0.00008629415,0.00003946538,0.0001150865,0.9902388,0.0002228823,0.0001011884,0.005099748],"study_design_scores_gemma":[0.00005222694,0.0005517753,0.03564342,0.00002905797,0.00004653461,0.0006042778,0.0001784269,0.002184441,0.9547026,0.0001962505,0.005802055,0.000008974806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951646,0.001514466,0.001909892,0.0001154735,0.00001549159,0.0000313327,0.0003012715,0.00007044736,0.0008769933],"genre_scores_gemma":[0.9968041,0.0004855698,0.001484308,0.00005158652,0.000008281369,0.0000317749,0.0002077147,0.000007170857,0.0009194766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008806834,"threshold_uncertainty_score":0.002946198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0687867065602474,"score_gpt":0.409275471952482,"score_spread":0.3404887653922346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}