{"id":"W4384120297","doi":"10.1158/1078-0432.ccr-22-3273","title":"Dual Role of CXCL8 in Maintaining the Mesenchymal State of Glioblastoma Stem Cells and M2-Like Tumor-Associated Macrophages","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Microsemi (Canada)","funders":"National Natural Science Foundation of China","keywords":"Mesenchymal stem cell; Cancer research; Paracrine signalling; Biology; Tumor microenvironment; PI3K/AKT/mTOR pathway; Tumor progression; Reprogramming; Stem cell; STAT3; Signal transduction; Cell; Cell biology; Cancer; Receptor; Genetics; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006696626,0.0001530839,0.0005584395,0.0002513283,0.0001488615,0.0000138052,0.0004745196,0.0002100363,0.000275887],"category_scores_gemma":[0.0003765192,0.0001167189,0.0001128346,0.0009988656,0.001926224,0.00005218268,0.0007193126,0.001403713,0.0001017723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001110867,"about_ca_system_score_gemma":0.0004167726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009916987,"about_ca_topic_score_gemma":0.0007501782,"domain_scores_codex":[0.9957339,0.001921656,0.000925644,0.0004258427,0.00021482,0.0007781552],"domain_scores_gemma":[0.9950923,0.003908093,0.0002477184,0.0004166461,0.0002973612,0.00003789041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004582276,0.0005210321,0.1020034,0.0002261076,0.0007242054,0.0001479557,0.005413592,0.0004590012,0.7915697,0.0002768964,0.0124849,0.0815909],"study_design_scores_gemma":[0.005928179,0.002389887,0.1580157,0.0005422406,0.00004728741,0.00001294913,0.007829734,0.0002911096,0.8092876,0.001642195,0.01361982,0.0003932176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991718,0.006561134,5.865928e-7,0.0003068028,0.0006556598,0.0003890741,0.0001324021,0.00002839026,0.0002079629],"genre_scores_gemma":[0.9948619,0.00217356,0.000003507089,0.00005028726,0.00003358838,0.00007172031,0.00000519375,0.00002891165,0.002771356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08119769,"threshold_uncertainty_score":0.7097252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0687867065602474,"score_gpt":0.409275471952482,"score_spread":0.3404887653922346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}