{"id":"W4384120373","doi":"10.1001/jamaoncol.2023.2163","title":"Management of Down Syndrome–Associated Leukemias","year":2023,"lang":"en","type":"review","venue":"JAMA Oncology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Cancer Institute; National Institutes of Health","keywords":"Medicine; Down syndrome; Myeloid leukemia; Internal medicine; Clinical trial; Leukemia; Population; Pediatrics; Oncology; Myeloid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001502199,0.0004871454,0.004291206,0.0007884065,0.00005610095,0.00001487248,0.0006187435,0.001665532,0.0005055981],"category_scores_gemma":[0.0004387604,0.0003899224,0.0008525052,0.00163391,0.0002419458,0.0000432794,0.0007305706,0.001718175,0.002501685],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006670711,"about_ca_system_score_gemma":0.003051208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001026026,"about_ca_topic_score_gemma":0.00001401909,"domain_scores_codex":[0.996042,0.0005365065,0.001294153,0.0006811429,0.0006573197,0.0007888413],"domain_scores_gemma":[0.9969357,0.0009528754,0.0007426553,0.0008958775,0.0002080728,0.0002648158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004450725,0.0002114875,0.000004273285,0.04970965,0.003412321,0.01583149,0.00003348999,2.526023e-7,3.25312e-7,0.0003910205,0.04888398,0.8814772],"study_design_scores_gemma":[0.002108304,0.0008990489,0.0001387743,0.02314174,0.003236678,0.001332829,0.00007799407,0.000008573985,5.094414e-7,0.00005039351,0.9687488,0.0002563474],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001192953,0.9551318,0.000004884892,0.0005610078,0.0004234693,0.002520009,0.0001209958,0.000220513,0.04089804],"genre_scores_gemma":[0.00001432838,0.9626356,0.0004277908,0.0001358533,0.0001617663,0.0004695273,0.0006918228,0.000162125,0.03530115],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9198648,"threshold_uncertainty_score":0.9998553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09827267579934236,"score_gpt":0.4235820109533521,"score_spread":0.3253093351540098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}