{"id":"W4384120576","doi":"10.1093/mmy/myad069","title":"<i>In vitro</i> combination of antifungal drugs with tacrolimus (FK506) holds promise against clinical <i>Candida</i> species, including <i>Candida auris</i>","year":2023,"lang":"en","type":"article","venue":"Medical Mycology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"Tehran University of Medical Sciences and Health Services","keywords":"Anidulafungin; Caspofungin; Tacrolimus; Itraconazole; Fluconazole; Echinocandin; Calcineurin; Microbiology; Pharmacology; Candida parapsilosis; Candida glabrata; Candida auris; Candida albicans; Biology; Medicine; Chemistry; Antifungal; Internal medicine; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003305253,0.0005867481,0.0005011501,0.0002848874,0.0002916953,0.0005235965,0.0003319609,0.0003207093,0.001545552],"category_scores_gemma":[0.0003118232,0.0001586772,0.0005458333,0.000240908,0.0001568948,0.0001696812,0.0001768606,0.0004773362,0.0006398018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000205848,"about_ca_system_score_gemma":0.0002454706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001084451,"about_ca_topic_score_gemma":0.002985938,"domain_scores_codex":[0.9994331,0.0002340204,0.00005556309,0.00006296249,0.0001177768,0.00009653653],"domain_scores_gemma":[0.9997278,0.00007067717,0.00007496087,0.00003513037,0.00004253857,0.00004886298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007990288,0.0005873941,0.002066486,0.0002390187,0.00007785507,0.0001250535,0.00002288103,0.0002484965,0.982978,0.00006148978,0.0007132922,0.0120809],"study_design_scores_gemma":[0.00007181206,0.008743796,0.01116854,0.00003218785,0.0002832607,0.001272094,0.00003671784,0.0005584675,0.9724275,0.00002776804,0.005361592,0.00001625156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9681363,0.01897581,0.002703691,0.0004639946,0.000273226,0.00009846423,0.0005777196,0.0001182986,0.008652616],"genre_scores_gemma":[0.9896761,0.0047844,0.002910159,0.0001714468,0.0001433758,0.00003095269,0.0009469711,0.00001416638,0.001322576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001545552,"threshold_uncertainty_score":0.005170345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02704373594122667,"score_gpt":0.3341809677153878,"score_spread":0.3071372317741611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}