{"id":"W4384120576","doi":"10.1093/mmy/myad069","title":"<i>In vitro</i> combination of antifungal drugs with tacrolimus (FK506) holds promise against clinical <i>Candida</i> species, including <i>Candida auris</i>","year":2023,"lang":"en","type":"article","venue":"Medical Mycology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"Tehran University of Medical Sciences and Health Services","keywords":"Anidulafungin; Caspofungin; Tacrolimus; Itraconazole; Fluconazole; Echinocandin; Calcineurin; Microbiology; Pharmacology; Candida parapsilosis; Candida glabrata; Candida auris; Candida albicans; Biology; Medicine; Chemistry; Antifungal; Internal medicine; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003105393,0.0003146963,0.001312202,0.0003225562,0.0001254668,0.00001341913,0.0003182879,0.0006110449,0.0003753738],"category_scores_gemma":[0.001811454,0.0002474281,0.0002189407,0.001281426,0.001122283,0.0001310135,0.0002163921,0.001073739,0.0000902251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001776363,"about_ca_system_score_gemma":0.001011438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008540092,"about_ca_topic_score_gemma":0.0001453838,"domain_scores_codex":[0.9954777,0.0004272108,0.001304084,0.0007542991,0.001224136,0.000812531],"domain_scores_gemma":[0.9972972,0.001109158,0.0003084364,0.0005452888,0.0002150732,0.0005248489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01147237,0.003073539,0.8352689,0.0008986345,0.0002614599,0.004327867,0.0009674163,0.000005202907,0.0773657,0.001049331,0.05495436,0.01035524],"study_design_scores_gemma":[0.03255214,0.00420314,0.870553,0.00107041,0.0003123359,0.0001855718,0.001302621,0.001696903,0.02950219,0.000720169,0.05701234,0.0008892542],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840072,0.0001578021,0.00009067532,0.005571673,0.0006388016,0.0008258765,0.00003781495,0.0001384987,0.008531597],"genre_scores_gemma":[0.9930235,0.0007609315,0.0001506249,0.003780511,0.0003699732,0.00005985461,0.000158497,0.00004473784,0.001651421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04786351,"threshold_uncertainty_score":0.9999978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02704373594122667,"score_gpt":0.3341809677153878,"score_spread":0.3071372317741611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}