{"id":"W4384120732","doi":"10.3324/haematol.2022.281944","title":"Cross-intolerance with bosutinib after prior tyrosine kinase inhibitors for Philadelphia chromosome-positive leukemia: long-term analysis of a phase I/II study","year":2023,"lang":"en","type":"letter","venue":"Haematologica","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Princess Margaret Cancer Centre","funders":"Pfizer","keywords":"Bosutinib; Philadelphia chromosome; Term (time); Medicine; Tyrosine kinase; Internal medicine; Genetics; Biology; Nilotinib; Chromosomal translocation; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002042711,0.0004647357,0.0009153595,0.0002237176,0.0007515277,0.001329275,0.0005282905,0.003156298,0.001205242],"category_scores_gemma":[0.003224746,0.0001904881,0.001052664,0.0004786238,0.0004912571,0.0005485023,0.000264468,0.002767511,0.0004328113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00162808,"about_ca_system_score_gemma":0.0007801894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009434952,"about_ca_topic_score_gemma":0.00218191,"domain_scores_codex":[0.9989225,0.0004873963,0.0001018692,0.000145613,0.0002008672,0.0001418956],"domain_scores_gemma":[0.9967859,0.001330512,0.0006386334,0.0001839203,0.0002516519,0.0008093804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.05779633,0.01221455,0.4584944,0.0008914643,0.004272431,0.09779508,0.001174847,0.001695252,0.04022921,0.00179086,0.08053309,0.2431125],"study_design_scores_gemma":[0.02311153,0.0933658,0.563438,0.0004397545,0.00416998,0.1609385,0.000996979,0.006868914,0.01343446,0.00242193,0.1306351,0.0001789548],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9503062,0.007461933,0.001226035,0.0296929,0.001141451,0.0003077885,0.001173571,0.0000866726,0.008603429],"genre_scores_gemma":[0.9562486,0.001537235,0.0005623112,0.03681156,0.0009290238,0.00009474668,0.0009110335,0.00003299888,0.002872399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003156298,"threshold_uncertainty_score":0.01181263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02871852075544904,"score_gpt":0.3321261415805384,"score_spread":0.3034076208250894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}