{"id":"W4384120739","doi":"10.3324/haematol.2023.283225","title":"Down syndrome and leukemia: from basic mechanisms to clinical advances","year":2023,"lang":"en","type":"review","venue":"Haematologica","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Cancer Institute; Cancer Council Western Australia; National Institutes of Health; Ministerio de Ciencia e Innovación; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; European Commission; St. Jude Children's Research Hospital; Children's Hospital of Philadelphia; American Lebanese Syrian Associated Charities; U.S. Department of Defense","keywords":"Down syndrome; Trisomy; Myeloid leukemia; Leukemia; Medicine; Acute leukemia; Population; Lymphoblastic Leukemia; Immunology; Bioinformatics; Oncology; Biology; Genetics; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008866118,0.00072229,0.001435568,0.001916183,0.0003089127,0.001369608,0.0007609254,0.001104332,0.003176561],"category_scores_gemma":[0.001481581,0.0002478427,0.0005511653,0.001869046,0.0006423175,0.001892842,0.00074831,0.002190492,0.0009772708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008484081,"about_ca_system_score_gemma":0.001707702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001296031,"about_ca_topic_score_gemma":0.001819266,"domain_scores_codex":[0.9997227,0.0000554148,0.00005475426,0.00004050176,0.00009697703,0.00002971494],"domain_scores_gemma":[0.999278,0.0004338908,0.00007346672,0.00001489173,0.0001506917,0.00004897884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001507431,0.00007058889,0.0005212068,0.02430527,0.0001250085,0.0006828904,0.0001478458,0.0003656554,0.001301102,0.008063031,0.05519069,0.909076],"study_design_scores_gemma":[0.00002185813,0.00009873012,0.001237242,0.009612341,0.0001305997,0.002205996,0.0001281768,0.00007103571,0.0002438284,0.004723067,0.9815044,0.00002278694],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006547572,0.9986963,0.00003403824,0.0006314816,0.0002247045,0.0000014565,0.000009421111,0.000003243978,0.0003340668],"genre_scores_gemma":[0.0003727302,0.9989754,0.00004885766,0.0002405289,0.0002311744,0.000001917638,0.00001339281,5.232306e-7,0.0001155126],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003176561,"threshold_uncertainty_score":0.01062667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1461542621685623,"score_gpt":0.4390545652284838,"score_spread":0.2929003030599215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}