{"id":"W4384131434","doi":"10.1186/s41231-023-00150-y","title":"Feasibility of manufacture of chimeric antigen receptor-regulatory T cells from patients with end-stage renal disease","year":2023,"lang":"en","type":"article","venue":"Translational Medicine Communications","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of British Columbia; Etablissement Français du Sang; Sangamo Therapeutics","keywords":"Transplantation; Human leukocyte antigen; Chimeric antigen receptor; Population; Medicine; End stage renal disease; Immunology; Cell therapy; Antigen; FOXP3; Kidney transplantation; T cell; Biology; Cell; Internal medicine; Disease; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003537431,0.0001656536,0.0004149672,0.0002522667,0.0001009122,0.000002505414,0.0004481753,0.00006683054,0.005934508],"category_scores_gemma":[0.00006975026,0.0001284474,0.0001063414,0.000682408,0.0009071182,0.00007228652,0.00006059926,0.0002956131,0.00001850084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004166161,"about_ca_system_score_gemma":0.000281763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002060912,"about_ca_topic_score_gemma":0.00005465256,"domain_scores_codex":[0.9978856,0.0001931457,0.0005322035,0.000248561,0.0009545091,0.0001860252],"domain_scores_gemma":[0.9967988,0.0006754769,0.0001879617,0.001744723,0.0003685904,0.0002244765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002518915,0.001172292,0.7481388,0.0002591248,0.0004735616,0.000002437276,0.002549314,0.0002663168,0.2325996,0.0007031093,0.001481675,0.009834848],"study_design_scores_gemma":[0.003234815,0.0002200187,0.9840696,0.0002686684,0.0001222619,2.020978e-7,0.0001050532,0.0002926359,0.005161489,0.0003259605,0.00609155,0.0001077854],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910691,0.0006248283,0.0001815783,0.005021368,0.00004806969,0.0009470608,0.00100896,0.00006038299,0.001038645],"genre_scores_gemma":[0.9920864,0.0003668103,0.001769576,0.00007419689,0.00005601087,0.00002861323,0.004916222,0.00003078787,0.0006714202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2359307,"threshold_uncertainty_score":0.9949742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06671789336631592,"score_gpt":0.3459377385188726,"score_spread":0.2792198451525567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}