{"id":"W4384131526","doi":"10.3389/fphar.2023.1157459","title":"Weight increase in people with cystic fibrosis on CFTR modulator therapy is mainly due to increase in fat mass","year":2023,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Hospital for Sick Children; Public Health Ontario; University of Toronto","funders":"","keywords":"Ivacaftor; Cystic fibrosis; Medicine; Internal medicine; Weight gain; Lean body mass; Cohort; Endocrinology; Prospective cohort study; Gastroenterology; Weight change; Weight loss; Obesity; Body weight; Cystic fibrosis transmembrane conductance regulator","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002657315,0.0002259,0.0003928929,0.0004222373,0.0002861824,0.0003730753,0.0001662631,0.0003449929,0.002164774],"category_scores_gemma":[0.001078472,0.0001424433,0.0004127041,0.0006837369,0.0002133926,0.0002341986,0.0003074431,0.0005435143,0.0002819916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001713856,"about_ca_system_score_gemma":0.0001550331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001747536,"about_ca_topic_score_gemma":0.002085629,"domain_scores_codex":[0.9998048,0.00003693676,0.00002270899,0.00004431743,0.00006194716,0.00002928502],"domain_scores_gemma":[0.9993739,0.00005842418,0.0004373748,0.00002621252,0.00003706088,0.00006719698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003681387,0.00007690525,0.9929641,0.0000497927,0.00007806688,0.0001030849,0.00004851584,0.0000128737,0.0008340263,0.000009326801,0.0001363183,0.005318756],"study_design_scores_gemma":[0.000007287358,0.0002016252,0.9991869,0.00001270423,0.00003325552,0.0002975545,0.00004848544,0.00002062092,0.00005535395,0.00001094726,0.0001239498,0.000001243604],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976793,0.001121949,0.00008825857,0.0001166324,0.00002066156,0.00001150208,0.0003461926,0.000006346459,0.0006092305],"genre_scores_gemma":[0.9988155,0.0004753462,0.00007766351,0.00006997196,0.00002172344,0.000009540161,0.000275721,0.000001786101,0.0002527908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002164774,"threshold_uncertainty_score":0.007241905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01015472460475637,"score_gpt":0.3011988454488789,"score_spread":0.2910441208441225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}