{"id":"W4384155464","doi":"10.1038/s41416-023-02344-5","title":"Combination of pembrolizumab and pelareorep promotes anti-tumour immunity in advanced pancreatic adenocarcinoma (PDAC)","year":2023,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"National Cancer Institute; Oncolytics Biotech; Merck","keywords":"Pembrolizumab; Medicine; Internal medicine; Chemotherapy; Oncology; CD8; Immunotherapy; Immune system; Gastroenterology; Regimen; Chemotherapy regimen; Immunology; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001900129,0.0002039945,0.0005865758,0.0001503016,0.0001392687,0.0003683072,0.0001439672,0.0002547221,0.001748632],"category_scores_gemma":[0.0002094211,0.0001276684,0.0003801336,0.0001415059,0.0001593902,0.0003226561,0.0001735364,0.001066164,0.0003613215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001726965,"about_ca_system_score_gemma":0.0002476967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002997455,"about_ca_topic_score_gemma":0.0007399003,"domain_scores_codex":[0.9998714,0.00002935551,0.000008376698,0.00001785238,0.00002159653,0.00005154332],"domain_scores_gemma":[0.9999241,0.00001679889,0.000008507056,0.000008782131,0.000005386682,0.00003650573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0588643,0.009428312,0.009217581,0.0009411401,0.0003940611,0.0005794246,0.0001761399,0.001814552,0.7218216,0.000268689,0.003189976,0.1933041],"study_design_scores_gemma":[0.01293078,0.3141403,0.2228805,0.0001533375,0.001925459,0.003725621,0.0007945768,0.009979106,0.3996376,0.000631367,0.03311732,0.00008406425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964888,0.002189924,0.0001570576,0.0001099335,0.0001023016,0.00003004491,0.0000781862,0.00002994696,0.0008137937],"genre_scores_gemma":[0.9980338,0.0007438861,0.0002830423,0.00007696636,0.00003776083,0.00003178558,0.0001303588,0.00000341887,0.0006590441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001748632,"threshold_uncertainty_score":0.005849719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01285381956689162,"score_gpt":0.2831648186824827,"score_spread":0.2703109991155911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}