{"id":"W4384197679","doi":"10.3389/fonc.2023.1206965","title":"Epigenetics in myeloproliferative neoplasms","year":2023,"lang":"en","type":"review","venue":"Frontiers in Oncology","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Health Service Executive; Wellcome Trust; Canadian Institute for Theoretical Astrophysics","keywords":"Epigenetics; Epigenome; DNA methylation; Histone; Biology; microRNA; Myelofibrosis; Cancer research; Bioinformatics; Epigenomics; Disease; Medicine; Genetics; Gene; Immunology; Internal medicine; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005230893,0.0007437944,0.00511193,0.001463227,0.00005379358,0.00001965402,0.0002477952,0.001227518,0.0001059733],"category_scores_gemma":[0.0003976588,0.0006013367,0.0004541085,0.001321879,0.0001825104,0.00004134987,0.0001482325,0.001232029,0.000367853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002741921,"about_ca_system_score_gemma":0.002263432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005626606,"about_ca_topic_score_gemma":0.0007054276,"domain_scores_codex":[0.995878,0.0005953584,0.001448261,0.0009744804,0.0003042459,0.0007996688],"domain_scores_gemma":[0.9981067,0.0006755506,0.0003945573,0.0005079286,0.00007812055,0.0002372099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009812044,0.0008090279,0.012286,0.005230119,0.0006161464,0.00340642,0.0005249743,0.000008224583,4.200771e-8,0.0003107422,0.02386316,0.952847],"study_design_scores_gemma":[0.002199421,0.001095837,0.0008520162,0.008626404,0.000680612,0.000149322,0.0001788167,0.00005944176,0.000002425491,0.0004120356,0.9853039,0.000439755],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009703722,0.9895923,0.00005733523,0.0004545413,0.002364005,0.00341749,0.00007354637,0.00007505427,0.003868667],"genre_scores_gemma":[0.000008419971,0.9865913,0.007547141,0.0002612375,0.0003322669,0.002500778,0.0003727344,0.0001418147,0.002244305],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9614407,"threshold_uncertainty_score":0.9996438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1053454154868902,"score_gpt":0.4279332036901433,"score_spread":0.3225877882032531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}