{"id":"W4384201122","doi":"10.1038/s41467-023-39891-7","title":"Structural journey of an insecticidal protein against western corn rootworm","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia, Okanagan Campus; Willow Biosciences (Canada)","funders":"Agricultural Research Service; Corteva Agriscience; Wellcome Trust; Iowa State University; Leibniz-Gemeinschaft; Plant Sciences Institute, Iowa State University; U.S. Department of Agriculture","keywords":"Western corn rootworm; Biology; Genetically modified crops; Transgene; PEST analysis; Genetically modified maize; Food security; Biotechnology; Computational biology; Agriculture; Gene; Biochemistry; Ecology; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009336149,0.0001624477,0.00009613687,0.00009569091,0.0001493282,0.0002262518,0.0002293571,0.0001984565,0.0004743141],"category_scores_gemma":[0.0001372075,0.0001032141,0.0001218772,0.0001028481,0.0001435633,0.0001861081,0.0001093455,0.0004834846,0.0001317173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004778347,"about_ca_system_score_gemma":0.0002442715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002411139,"about_ca_topic_score_gemma":0.001787783,"domain_scores_codex":[0.999967,0.000003642545,0.000001601553,0.000006581221,0.00001336691,0.00000790773],"domain_scores_gemma":[0.9999604,0.000006233299,0.0000124844,0.000002937121,0.000008109876,0.000009805289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000709774,0.00002142624,0.0004779107,0.00003196716,0.000004849661,0.0001088165,0.00004686901,0.0007006727,0.9968295,0.0003043066,0.0001015914,0.001301173],"study_design_scores_gemma":[0.00002281488,0.0002569324,0.01248254,0.00001570599,0.00002583678,0.0005343673,0.0002161913,0.0136985,0.9659515,0.000325246,0.006455625,0.00001476305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970714,0.0003970395,0.001301036,0.0001232371,0.000006199377,0.000008406304,0.0001391778,0.00003677375,0.0009167248],"genre_scores_gemma":[0.9947345,0.0004827982,0.002539326,0.0000671937,0.000003854363,0.000006835694,0.0006968507,0.00001397472,0.001454563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002411139,"threshold_uncertainty_score":0.00479418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02107655715783808,"score_gpt":0.3135492253423545,"score_spread":0.2924726681845164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}