{"id":"W4384201122","doi":"10.1038/s41467-023-39891-7","title":"Structural journey of an insecticidal protein against western corn rootworm","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia, Okanagan Campus; Willow Biosciences (Canada)","funders":"Agricultural Research Service; Corteva Agriscience; Wellcome Trust; Iowa State University; Leibniz-Gemeinschaft; Plant Sciences Institute, Iowa State University; U.S. Department of Agriculture","keywords":"Western corn rootworm; Biology; Genetically modified crops; Transgene; PEST analysis; Genetically modified maize; Food security; Biotechnology; Computational biology; Agriculture; Gene; Biochemistry; Ecology; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001386775,0.0001061504,0.000108137,0.00006321156,0.0001701528,0.00001967174,0.000784998,0.0002759277,0.000003174678],"category_scores_gemma":[0.000081654,0.0001014578,0.00006155318,0.0002500771,0.0001166677,0.000005667904,0.0002695928,0.0003638372,0.000006749542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000106593,"about_ca_system_score_gemma":0.00008534043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001014068,"about_ca_topic_score_gemma":0.002235301,"domain_scores_codex":[0.9992662,0.00009630383,0.0001913278,0.0001548156,0.0001224176,0.0001689405],"domain_scores_gemma":[0.9982615,0.00001429098,0.000102493,0.00138901,0.0001773925,0.00005531537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006332349,0.00006464632,0.01038102,0.00002324656,0.00006128201,0.000001878329,0.0002303619,0.0001379069,0.98461,0.0005904196,0.00112322,0.002712655],"study_design_scores_gemma":[0.0012669,0.0006320792,0.3394203,0.00008220507,0.00005163974,0.00002386781,0.0004985948,0.001413201,0.5817186,0.0007252548,0.07348625,0.000681174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968434,0.001257605,0.00001182981,0.0003814994,0.00008374549,0.0001950852,0.00004401585,0.00002707717,0.001155765],"genre_scores_gemma":[0.9971328,0.0002555313,0.001210315,0.0002068427,0.0001029849,0.00002414629,0.0006689835,0.00001959716,0.0003788464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4028915,"threshold_uncertainty_score":0.4137327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02107655715783808,"score_gpt":0.3135492253423545,"score_spread":0.2924726681845164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}