{"id":"W4384202159","doi":"10.1038/s41419-023-05936-4","title":"A Dhdds K42E knock-in RP59 mouse model shows inner retina pathology and defective synaptic transmission","year":2023,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Center for Advancing Translational Sciences; Natural Sciences and Engineering Research Council of Canada; Narodowe Centrum Nauki; Ögonfonden; National Eye Institute; University of Guelph; University at Buffalo; Knights Templar Eye Foundation; U.S. Department of Veterans Affairs; U.S. Department of Health and Human Services; National Institutes of Health; Government of Canada","keywords":"Outer nuclear layer; Retinal degeneration; Retina; Retinitis pigmentosa; Biology; Retinal; Electroretinography; Inner nuclear layer; Outer plexiform layer; Photoreceptor cell; Cell biology; Molecular biology; Neuroscience; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002895267,0.001478463,0.0005399774,0.001845038,0.0005502087,0.0005639021,0.0006448682,0.00143521,0.005130793],"category_scores_gemma":[0.0001856154,0.0005786844,0.0008600557,0.0005013604,0.0007958811,0.0005331148,0.0005593904,0.001736714,0.001507891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004474444,"about_ca_system_score_gemma":0.0002757225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00116233,"about_ca_topic_score_gemma":0.001612526,"domain_scores_codex":[0.9992873,0.00005489078,0.0001181366,0.0002574396,0.0001912124,0.00009096695],"domain_scores_gemma":[0.9994845,0.0000399278,0.000213276,0.00005221003,0.00004534248,0.0001646617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002614582,0.0001459239,0.0005536529,0.00009089215,0.00003089903,0.0007530605,0.00005720449,0.00009278159,0.9957432,0.0003681608,0.0001781557,0.001724561],"study_design_scores_gemma":[0.0001635349,0.001625656,0.02134051,0.0001185516,0.0001765385,0.007079316,0.0002826837,0.002272021,0.9569304,0.0005695985,0.009391561,0.00004955945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741674,0.001919728,0.01198261,0.0004923991,0.0002040831,0.0001969609,0.005619688,0.000939537,0.004477777],"genre_scores_gemma":[0.9622228,0.002502995,0.01029431,0.0002910158,0.00004818641,0.000406226,0.004141115,0.0002875802,0.0198058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005130793,"threshold_uncertainty_score":0.01716423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008374012081549911,"score_gpt":0.224053561230038,"score_spread":0.2156795491484881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}