{"id":"W4384283495","doi":"10.1016/j.fitote.2023.105613","title":"Rapid screening of active ingredients and action mechanisms of Ecliptae Herba for treating Alzheimer's disease by UPLC-Q-TOF/MS and “component-target-pathway” network","year":2023,"lang":"en","type":"article","venue":"Fitoterapia","topic":"Medicinal Plants and Neuroprotection","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"","keywords":"Luteolin; Apigenin; Chlorogenic acid; Rosmarinic acid; Drug discovery; Pharmacology; Drug; Chemistry; Quercetin; Medicine; Biochemistry; Flavonoid; Chromatography; Antioxidant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002851382,0.0008705548,0.0007433309,0.001439421,0.0004569697,0.0004136362,0.0002772723,0.0005803813,0.003148993],"category_scores_gemma":[0.0004039628,0.0002699276,0.000896261,0.0006427088,0.00024812,0.0007251118,0.0004851542,0.00075021,0.0008203037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002464879,"about_ca_system_score_gemma":0.0005461659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004640834,"about_ca_topic_score_gemma":0.0009319618,"domain_scores_codex":[0.9998345,0.00001655417,0.00001222998,0.0000457268,0.00006618795,0.00002468529],"domain_scores_gemma":[0.9998941,0.00003040925,0.00002648465,0.000006086266,0.00002811468,0.00001471188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003091256,0.0000688936,0.0004588688,0.000280552,0.00005384944,0.0001227927,0.00002141805,0.0001349411,0.984605,0.0001804313,0.000201436,0.01356263],"study_design_scores_gemma":[0.0001796296,0.0009311363,0.01284713,0.00005079104,0.0004112693,0.00117198,0.00008151657,0.006631335,0.9636178,0.0005965749,0.01341209,0.00006866865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8591522,0.02196955,0.09612957,0.0008043551,0.0002462908,0.001242899,0.00755067,0.001892093,0.01101237],"genre_scores_gemma":[0.8674059,0.008370867,0.1084781,0.000850812,0.00007819613,0.0007716438,0.00518407,0.000173093,0.008687262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003148993,"threshold_uncertainty_score":0.01053447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04165822459023025,"score_gpt":0.2795826521340424,"score_spread":0.2379244275438122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}