{"id":"W4384283495","doi":"10.1016/j.fitote.2023.105613","title":"Rapid screening of active ingredients and action mechanisms of Ecliptae Herba for treating Alzheimer's disease by UPLC-Q-TOF/MS and “component-target-pathway” network","year":2023,"lang":"en","type":"article","venue":"Fitoterapia","topic":"Medicinal Plants and Neuroprotection","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"","keywords":"Luteolin; Apigenin; Chlorogenic acid; Rosmarinic acid; Drug discovery; Pharmacology; Drug; Chemistry; Quercetin; Medicine; Biochemistry; Flavonoid; Chromatography; Antioxidant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002211061,0.0001571563,0.0003382395,0.0001209541,0.0001222091,0.000008712836,0.0000353363,0.00009209601,0.00002339182],"category_scores_gemma":[0.00007882091,0.0001358411,0.00006140974,0.0001812927,0.00005008363,0.000104665,0.00003555077,0.0001600973,6.739479e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009772692,"about_ca_system_score_gemma":0.00001836279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008196322,"about_ca_topic_score_gemma":0.000002038012,"domain_scores_codex":[0.9989272,0.00004691911,0.0002890976,0.0002841431,0.0002238863,0.0002287644],"domain_scores_gemma":[0.9992824,0.0001378646,0.0002203379,0.0001289214,0.00006024936,0.0001702373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008186611,0.0002076074,0.005405981,0.001037617,0.0006767462,0.00004014208,0.001225599,0.00008943197,0.5880069,0.000126935,0.003039857,0.3919565],"study_design_scores_gemma":[0.01451851,0.006603393,0.2879714,0.004133077,0.001471169,0.0001010246,0.001334911,0.07629488,0.5961686,0.002983293,0.007583882,0.0008358791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929825,0.0009352684,0.004466425,0.0002316192,0.0003552196,0.0007950166,0.0001337356,0.00005990137,0.00004032962],"genre_scores_gemma":[0.9974925,0.0002457765,0.001587589,0.00008668283,0.0002574471,0.00004023167,0.0001847049,0.00002864607,0.00007645664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3911207,"threshold_uncertainty_score":0.5539439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04165822459023025,"score_gpt":0.2795826521340424,"score_spread":0.2379244275438122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}