{"id":"W4384299508","doi":"10.3390/ijms241411419","title":"Real-World Use of Highly Sensitive Liquid Biopsy Monitoring in Metastatic Breast Cancer Patients Treated with Endocrine Agents after Exposure to Aromatase Inhibitors","year":2023,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Instituto de Salud Carlos III; CRIS Cancer Foundation; Sociedad Española de Oncología Médica; University of Toronto","keywords":"Fulvestrant; Metastatic breast cancer; Internal medicine; Oncology; Anastrozole; Breast cancer; Medicine; Aromatase; Aromatase inhibitor; Population; Liquid biopsy; Regimen; KRAS; Cancer; Estrogen receptor; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005973098,0.0002612127,0.0003593178,0.0005186544,0.0002116277,0.0007121016,0.0002603529,0.0003094442,0.0004118997],"category_scores_gemma":[0.00133699,0.0001541757,0.000147165,0.0004764403,0.0002701949,0.0002045106,0.0002895228,0.0002915273,0.0001878273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000222876,"about_ca_system_score_gemma":0.0002123011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001120151,"about_ca_topic_score_gemma":0.001404008,"domain_scores_codex":[0.9993525,0.0002079253,0.00004563767,0.0001913511,0.0001523899,0.00005019039],"domain_scores_gemma":[0.9992769,0.0002049749,0.0002601873,0.00005557836,0.0001227845,0.00007948874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002274545,0.0002052685,0.87736,0.00008286199,0.0001024091,0.0008031777,0.0005566169,0.001060194,0.08701701,0.0001067371,0.0003243139,0.03010688],"study_design_scores_gemma":[0.00007073263,0.001928317,0.9259342,0.00003385677,0.0001834875,0.003297468,0.0006031397,0.008898878,0.05570652,0.0001988976,0.003105415,0.0000391221],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966745,0.0004991841,0.001778332,0.00004809441,0.000009192759,0.00002935103,0.0004692125,0.00003512728,0.0004569527],"genre_scores_gemma":[0.9975271,0.0001691301,0.001591172,0.0000725205,0.00001494369,0.00002673871,0.0004235284,0.000005938442,0.0001690361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001120151,"threshold_uncertainty_score":0.003158927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01460955053797841,"score_gpt":0.2885706023898471,"score_spread":0.2739610518518686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}