{"id":"W4384338919","doi":"10.1021/acs.joc.3c00956","title":"Synthesis of Sialyl Lewis<sup>X</sup> Mimetics with E- and P-Selectin Binding Properties and Immunosuppressive Activity","year":2023,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Université de Montréal; Montreal Clinical Research Institute","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Glycomics Network; Canadian Institutes of Health Research","keywords":"Selectin; Chemistry; Moiety; Bicyclic molecule; In vivo; Stereochemistry; Immune system; E-selectin; In vitro; Stereoselectivity; Cell adhesion; Biochemistry; Adhesion; Cell; Immunology; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008097543,0.0002204636,0.0001601587,0.00008885136,0.00007232445,0.0001057799,0.0001746406,0.0001444241,0.0009119857],"category_scores_gemma":[0.0001000576,0.00005803064,0.000115027,0.0001397869,0.00008383775,0.0001232025,0.000174908,0.0002417645,0.0002583161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000110001,"about_ca_system_score_gemma":0.0001778633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001529199,"about_ca_topic_score_gemma":0.0002429464,"domain_scores_codex":[0.9999574,0.000007101799,0.000004431487,0.000007145094,0.0000103755,0.00001356029],"domain_scores_gemma":[0.9999573,0.000004325419,0.00001411316,0.000003523036,0.000005550702,0.00001511097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001132213,0.00002001717,0.0001085617,0.00006074231,0.0000066162,0.00009380966,0.00001696596,0.000312911,0.9929296,0.0003486296,0.00005929301,0.005929595],"study_design_scores_gemma":[0.00002800993,0.0008493606,0.0009752006,0.000005283876,0.00001989318,0.0003325283,0.00001339409,0.0008455609,0.9925858,0.00007980427,0.004257192,0.000007802727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826119,0.00167783,0.01041297,0.00006595811,0.00003597822,0.00009377738,0.0003215886,0.0000730247,0.004706844],"genre_scores_gemma":[0.9840834,0.00125316,0.01191512,0.00006674088,0.00001265655,0.00005201455,0.0002831589,0.00001715585,0.0023166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009119857,"threshold_uncertainty_score":0.003050864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02231780459508113,"score_gpt":0.253955162996816,"score_spread":0.2316373584017349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}