{"id":"W4384339088","doi":"10.4049/jimmunol.2300083","title":"Human Granzyme K Is a Feature of Innate T Cells in Blood, Tissues, and Tumors, Responding to Cytokines Rather than TCR Stimulation","year":2023,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"National Institute of Allergy and Infectious Diseases; Science Foundation Ireland","keywords":"Cytotoxic T cell; Granzyme B; Biology; Interleukin 21; Granzyme; NK-92; Innate immune system; Immunology; Cell biology; Population; Interleukin 12; Perforin; CD8; Immune system; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007001522,0.0001283871,0.0003229243,0.000947091,0.0001180521,0.000008477867,0.0001993469,0.0001741007,0.0002435745],"category_scores_gemma":[0.0000750941,0.00008997553,0.00006140255,0.0005780909,0.0001176552,0.0001126492,0.00008463825,0.0004903475,0.00008077604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002476679,"about_ca_system_score_gemma":0.00002294998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009731137,"about_ca_topic_score_gemma":0.00001670517,"domain_scores_codex":[0.9987608,0.0004339328,0.0004560813,0.0001016516,0.00004025953,0.0002072401],"domain_scores_gemma":[0.999157,0.0001642763,0.0003686549,0.0001740231,0.0001256674,0.00001044264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001042382,0.00004906205,0.001031215,0.000008181945,0.0001546679,0.000009301003,0.003681362,0.00006046506,0.9880559,0.0001683016,0.005264062,0.0004751297],"study_design_scores_gemma":[0.002454418,0.001396314,0.06718715,0.0002027315,0.00009306172,0.0005941067,0.002104689,0.000007981049,0.8984027,0.000247289,0.02716206,0.0001475307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945762,0.002852283,0.00001421432,0.001225162,0.00102919,0.0001317976,0.00000328692,0.0000152445,0.0001526069],"genre_scores_gemma":[0.9864938,0.0004291943,0.00001615093,0.0001349403,0.00003022531,0.000001830555,0.00000749654,0.00001432506,0.0128721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0896532,"threshold_uncertainty_score":0.3669095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01274211683877087,"score_gpt":0.2614247357974426,"score_spread":0.2486826189586717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}