{"id":"W4384339088","doi":"10.4049/jimmunol.2300083","title":"Human Granzyme K Is a Feature of Innate T Cells in Blood, Tissues, and Tumors, Responding to Cytokines Rather than TCR Stimulation","year":2023,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"National Institute of Allergy and Infectious Diseases; Science Foundation Ireland","keywords":"Cytotoxic T cell; Granzyme B; Biology; Interleukin 21; Granzyme; NK-92; Innate immune system; Immunology; Cell biology; Population; Interleukin 12; Perforin; CD8; Immune system; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008140583,0.000362499,0.000229608,0.0004696086,0.0001584699,0.000476833,0.0001663166,0.0002968246,0.002884475],"category_scores_gemma":[0.0002127068,0.0001117567,0.000249803,0.0003798822,0.000241846,0.000260121,0.0004511339,0.0004504667,0.001045221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002088542,"about_ca_system_score_gemma":0.0001399635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002822762,"about_ca_topic_score_gemma":0.0002213297,"domain_scores_codex":[0.9998646,0.00001611846,0.0000152022,0.00005536403,0.00002628285,0.0000222727],"domain_scores_gemma":[0.9999082,0.00001013046,0.00004700888,0.00001151662,0.000009116825,0.00001410893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005725814,0.00002913194,0.009750415,0.0002087002,0.00004125478,0.0005162248,0.0000966037,0.00008073967,0.9639675,0.0002158119,0.000328526,0.02419257],"study_design_scores_gemma":[0.00008205722,0.0009662689,0.135327,0.0001380415,0.0001966191,0.01932435,0.0003924939,0.0007812698,0.7992631,0.001197136,0.04229352,0.00003812225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768552,0.01185599,0.00635183,0.0002493923,0.0000554495,0.00006352572,0.001400108,0.0002708941,0.00289765],"genre_scores_gemma":[0.9891925,0.003242041,0.002170396,0.0001118307,0.00003164949,0.00003602839,0.001296929,0.00004053602,0.003878024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002884475,"threshold_uncertainty_score":0.009649515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01274211683877087,"score_gpt":0.2614247357974426,"score_spread":0.2486826189586717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}