{"id":"W4384339320","doi":"10.1158/2159-8290.cd-22-0412","title":"Spectrum of Response to Platinum and PARP Inhibitors in Germline <i>BRCA</i> –Associated Pancreatic Cancer in the Clinical and Preclinical Setting","year":2023,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Ontario Institute for Cancer Research","funders":"Terry Fox Research Institute; Tel Aviv University; Hebrew University of Jerusalem; Canadian Cancer Society Research Institute; Ministry of Science, Technology and Space; Israel Science Foundation; Pancreatic Cancer Canada Foundation; Princess Margaret Cancer Foundation; Deutsches Krebsforschungszentrum; AstraZeneca","keywords":"Germline; Pancreatic cancer; Poly ADP ribose polymerase; Cancer research; PARP inhibitor; Olaparib; Medicine; BRCA mutation; Cancer; Germline mutation; Biology; Genetics; Bioinformatics; Oncology; Mutation; Polymerase; Ovarian cancer; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004540984,0.0001734095,0.000270724,0.0002156897,0.0001523365,0.0004370304,0.0001507933,0.0002458549,0.0008481951],"category_scores_gemma":[0.000487429,0.0001034519,0.000157252,0.0001927294,0.0002503906,0.0002429559,0.0002014103,0.0004355029,0.0001474229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003057579,"about_ca_system_score_gemma":0.0001614065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003409435,"about_ca_topic_score_gemma":0.0004653293,"domain_scores_codex":[0.9998617,0.00004037263,0.00001406337,0.00003151381,0.00003024054,0.00002206011],"domain_scores_gemma":[0.999786,0.00006574256,0.0000626444,0.00002154459,0.00002165143,0.00004244282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01014148,0.00118045,0.1511229,0.0001993028,0.0001193104,0.0006442075,0.0001980192,0.003567527,0.7857424,0.0001742507,0.0007554115,0.0461547],"study_design_scores_gemma":[0.0005741335,0.04938922,0.554032,0.00002878276,0.0002776756,0.006770988,0.000369526,0.007314881,0.3763067,0.000267497,0.004633668,0.0000350288],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99891,0.0003212068,0.0001405565,0.00002374937,0.000002891213,0.00001423997,0.0001610343,0.00001727558,0.0004090709],"genre_scores_gemma":[0.9990422,0.0001381244,0.0002405367,0.00001634744,0.000003448064,0.00001088114,0.0003450956,0.000003237643,0.0002000692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008481951,"threshold_uncertainty_score":0.002837539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04817231314042761,"score_gpt":0.3999997935053252,"score_spread":0.3518274803648975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}