{"id":"W4384339320","doi":"10.1158/2159-8290.cd-22-0412","title":"Spectrum of Response to Platinum and PARP Inhibitors in Germline <i>BRCA</i> –Associated Pancreatic Cancer in the Clinical and Preclinical Setting","year":2023,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Ontario Institute for Cancer Research","funders":"Terry Fox Research Institute; Tel Aviv University; Hebrew University of Jerusalem; Canadian Cancer Society Research Institute; Ministry of Science, Technology and Space; Israel Science Foundation; Pancreatic Cancer Canada Foundation; Princess Margaret Cancer Foundation; Deutsches Krebsforschungszentrum; AstraZeneca","keywords":"Germline; Pancreatic cancer; Poly ADP ribose polymerase; Cancer research; PARP inhibitor; Olaparib; Medicine; BRCA mutation; Cancer; Germline mutation; Biology; Genetics; Bioinformatics; Oncology; Mutation; Polymerase; Ovarian cancer; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002776698,0.0001886131,0.0006198311,0.0002074025,0.00004273245,0.00002991077,0.0001000274,0.0001570582,0.00003170772],"category_scores_gemma":[0.0009458696,0.0001450436,0.00008243617,0.0009255314,0.0002642244,0.0001449554,0.00008315489,0.000458388,0.00000287549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001812861,"about_ca_system_score_gemma":0.0004337007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004381303,"about_ca_topic_score_gemma":0.001942036,"domain_scores_codex":[0.9974023,0.0005180013,0.0009301791,0.0004584948,0.0003220089,0.0003690796],"domain_scores_gemma":[0.997342,0.002019126,0.000207891,0.0002828145,0.00003446491,0.0001137142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003783686,0.0001181729,0.9845048,0.00009852669,0.00006101417,0.00005259341,0.001899881,0.0001680332,0.003392704,0.00002121649,0.002980355,0.002919033],"study_design_scores_gemma":[0.004866634,0.0003383907,0.9894773,0.001688409,0.00005758365,0.000005926018,0.0006572757,0.0002897276,0.001295652,0.0003479137,0.0008049539,0.0001702554],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802175,0.001773391,0.000005450128,0.01659958,0.0003347736,0.0007444124,0.0001902059,0.0000330041,0.0001016789],"genre_scores_gemma":[0.9935206,0.003045985,0.0000271013,0.002462593,0.000343644,0.0002786581,0.00001315363,0.00003035942,0.000277912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01413699,"threshold_uncertainty_score":0.5914705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04817231314042761,"score_gpt":0.3999997935053252,"score_spread":0.3518274803648975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}