{"id":"W4384405586","doi":"10.1038/s41390-023-02722-y","title":"Relationship between longitudinal changes in neuropsychological outcome and disease biomarkers in urea cycle disorders","year":2023,"lang":"en","type":"article","venue":"Pediatric Research","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","keywords":"Neuropsychology; Urea cycle; Hyperammonemia; Interim; Biomarker; Glutamine; Psychology; Neuropsychological assessment; Neuropsychological test; Internal medicine; Medicine; Cognition; Psychiatry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001297066,0.0001123782,0.0001315657,0.0005508634,0.00008467964,0.00002932736,0.0002078271,0.0001127295,0.00001357818],"category_scores_gemma":[0.001679706,0.0001053467,0.00003262806,0.001277831,0.0001374969,0.000004451514,0.0002255226,0.0002360043,0.00003481621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004259905,"about_ca_system_score_gemma":0.00005397683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007653604,"about_ca_topic_score_gemma":0.0003589582,"domain_scores_codex":[0.9981995,0.0003294814,0.0002117815,0.00048747,0.0002899895,0.0004817604],"domain_scores_gemma":[0.9992462,0.0002158007,0.00002525706,0.0002713506,0.00002532883,0.0002160565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007968531,0.00003847744,0.9969997,0.00003605972,0.000003397124,0.00001215978,0.00002649366,0.00002377959,0.00004691357,0.00004558104,0.0009408155,0.001746949],"study_design_scores_gemma":[0.0005753104,0.00006376686,0.9961277,0.000001652011,0.000006712773,3.399032e-7,0.00006388641,0.00003664564,0.000003074855,0.002208271,0.0007974767,0.0001151889],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945467,0.001474778,0.00001472159,0.003156669,0.00006207412,0.0002864203,0.00001973071,0.00001239921,0.0004265539],"genre_scores_gemma":[0.997032,0.002357203,0.00002750864,0.00002976564,0.0001926046,0.00005805572,0.0000920693,0.00001573636,0.0001950381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003126904,"threshold_uncertainty_score":0.4295912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1143700186663298,"score_gpt":0.4119914923398281,"score_spread":0.2976214736734982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}