{"id":"W4384405735","doi":"10.3899/jrheum.2023-0112","title":"Relationship Between Paraoxonase-1 Genotype and Activity, and Major Adverse Cardiovascular Events and Malignancies in Patients With Rheumatoid Arthritis Receiving Tofacitinib","year":2023,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Paraoxonase enzyme and polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"CSL Behring; Gilead Sciences; Pfizer","keywords":"Medicine; Paraoxonase; PON1; Internal medicine; Mace; Arylesterase; Rheumatoid arthritis; Phenylacetate; Tofacitinib; Oncology; Adverse effect; Gastroenterology; Genotype; Myocardial infarction; Biology; Oxidative stress; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006179024,0.0001314463,0.0003228876,0.000106455,0.0001112793,0.000007783697,0.00008562308,0.0001135639,0.000002227452],"category_scores_gemma":[0.0001560845,0.00009703306,0.00004448688,0.0001180334,0.0001497957,0.00001867396,0.0001007706,0.0001588122,0.000002223799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006492525,"about_ca_system_score_gemma":0.00004214512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008302047,"about_ca_topic_score_gemma":0.00009113685,"domain_scores_codex":[0.9990159,0.0002423558,0.0002540951,0.0001455695,0.0001390713,0.0002029717],"domain_scores_gemma":[0.9993698,0.0001732034,0.0001730684,0.0001611472,0.00004838083,0.00007440535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001910843,0.00001085686,0.9977907,0.00001824564,0.0001272771,0.000005137019,0.0001816619,0.00002456881,0.0002793304,0.00002093379,0.00008266365,0.001267542],"study_design_scores_gemma":[0.001998435,0.0002219724,0.9958122,0.0001064794,0.00003233963,0.0004710104,0.00008216592,0.000004052923,0.0005811801,0.0001716869,0.00039935,0.0001191607],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952775,0.004305259,0.00007601744,0.0001369001,0.00005100556,0.0001178091,0.00001968588,0.000004688482,0.00001108442],"genre_scores_gemma":[0.9950655,0.004800826,0.0000623244,0.00001637662,0.0000080805,0.000003225591,0.00001411441,0.00001430518,0.00001522787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001978531,"threshold_uncertainty_score":0.3956893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01334212728678245,"score_gpt":0.2260144469545955,"score_spread":0.212672319667813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}