{"id":"W4384405818","doi":"10.1101/2023.07.14.549057","title":"Ebola Virus VP35 Interacts Non-Covalently with Ubiquitin Chains to Promote Viral Replication Creating New Therapeutic Opportunities","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Ebola virus; Ebolavirus; Polymerase; Viral replication; Ubiquitin; Virology; Virus; VP40; Biology; Docking (animal); Cell biology; Genetics; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001462757,0.0004605995,0.0005367931,0.0001719513,0.0002433201,0.0005067468,0.0004429433,0.0004116826,0.002162241],"category_scores_gemma":[0.0001543721,0.0001877276,0.0007069592,0.0001389523,0.0002608101,0.0005637742,0.00051472,0.000568308,0.0003134918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004291976,"about_ca_system_score_gemma":0.0003336361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007865127,"about_ca_topic_score_gemma":0.000785694,"domain_scores_codex":[0.9999366,0.00001345997,0.000002825065,0.00001214858,0.00001997724,0.00001493203],"domain_scores_gemma":[0.9999676,0.000008663174,0.000008683091,0.00000341115,0.000004849526,0.000006746102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007800839,0.0006055583,0.004851115,0.00154974,0.0004327577,0.0009237577,0.00009783935,0.2992269,0.5970594,0.02658413,0.002674391,0.06521427],"study_design_scores_gemma":[0.0003814171,0.001928162,0.003251622,0.0002024587,0.0004710663,0.00095314,0.0001874224,0.6826154,0.2435401,0.01821927,0.04813548,0.0001144628],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8501856,0.03464003,0.09804507,0.001536496,0.0002941845,0.0001450593,0.0005411297,0.0005431673,0.01406917],"genre_scores_gemma":[0.9689163,0.008314657,0.01965392,0.0001939503,0.00003080083,0.00008865001,0.0002739005,0.00003200132,0.002495824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002162241,"threshold_uncertainty_score":0.007233441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07295882160151973,"score_gpt":0.3159793686128868,"score_spread":0.243020547011367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}