{"id":"W4384408426","doi":"10.1016/j.jaci.2023.06.024","title":"RelB-deficient autoinflammatory pathology presents as interferonopathy, but in mice is interferon-independent","year":2023,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Science Foundation","keywords":"RELB; Medicine; Pathology; Immunology; Biology; Genetics; Transcription factor; NFKB1","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000351728,0.0009821352,0.000344561,0.0009862459,0.0003302733,0.0005674693,0.0002909401,0.0008435248,0.004240908],"category_scores_gemma":[0.0002062853,0.0004414742,0.000434376,0.0002478101,0.0007756685,0.0003904885,0.0003141018,0.001496705,0.001348777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002572442,"about_ca_system_score_gemma":0.000249359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001493019,"about_ca_topic_score_gemma":0.0004015955,"domain_scores_codex":[0.9994705,0.00007083468,0.00006027206,0.0002011724,0.0001221536,0.00007506762],"domain_scores_gemma":[0.9993353,0.00007538876,0.0003245368,0.00006828386,0.00003774461,0.0001586691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001360185,0.00004260809,0.0002870855,0.00005348438,0.000008384879,0.0001475125,0.00001440069,0.00001546882,0.9985818,0.0001077304,0.00006363135,0.0005419544],"study_design_scores_gemma":[0.0001474489,0.0009556331,0.01995481,0.0001548236,0.00008607862,0.007703131,0.000163769,0.0008305104,0.9615192,0.0005704236,0.007889984,0.00002420402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.973232,0.00394285,0.01218111,0.0007652473,0.0001994129,0.0001322553,0.003387594,0.0009479306,0.005211543],"genre_scores_gemma":[0.9737357,0.002338666,0.01122708,0.0004680545,0.00006630763,0.0002412387,0.002343168,0.0003791587,0.009200563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004240908,"threshold_uncertainty_score":0.01418722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0212418990484644,"score_gpt":0.3057355954312393,"score_spread":0.2844936963827749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}