{"id":"W4384432207","doi":"10.1016/j.celrep.2023.112792","title":"ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Gray Foundation; Alvin J. Siteman Cancer Center; Foundation for Barnes-Jewish Hospital; U.S. Department of Defense","keywords":"Replication (statistics); Cell biology; DNA replication; Computational biology; DNA; Biology; Chemistry; Genetics; Virology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000474833,0.000179098,0.0001573205,0.00003447326,0.0001310546,0.00004488915,0.00009260692,0.0002013507,0.000008426546],"category_scores_gemma":[0.0002333331,0.0001777898,0.00007875598,0.0001576276,0.00001997862,0.000008686343,0.000210063,0.00008646745,0.0000145884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001969242,"about_ca_system_score_gemma":0.00006667667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002624243,"about_ca_topic_score_gemma":0.00002158351,"domain_scores_codex":[0.998386,0.00003870148,0.0003099208,0.0007883169,0.0001801977,0.0002968186],"domain_scores_gemma":[0.9986064,0.00001246507,0.0002438458,0.0009830841,0.00006688698,0.00008735344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001227805,0.00002084772,0.0001947856,0.00004769941,0.00001439255,0.0001232098,0.00004526192,0.00001227811,0.9964496,0.0001409342,0.001306277,0.001632365],"study_design_scores_gemma":[0.0001840277,0.000159918,0.0005567215,0.00002087153,0.00001846939,0.0001927915,0.00005020727,0.0002197273,0.980922,0.006292576,0.01116824,0.0002143878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706571,0.0001159925,0.02286945,0.00010873,0.0002553946,0.0006846142,0.000001993638,0.000173292,0.005133399],"genre_scores_gemma":[0.9907467,0.00004471748,0.004481504,0.0000903028,0.0001144924,0.0001580191,0.0001556302,0.00004970046,0.004158978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02008953,"threshold_uncertainty_score":0.7250058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01300316461328688,"score_gpt":0.250743005376014,"score_spread":0.2377398407627271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}