{"id":"W4384432207","doi":"10.1016/j.celrep.2023.112792","title":"ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Gray Foundation; Alvin J. Siteman Cancer Center; Foundation for Barnes-Jewish Hospital; U.S. Department of Defense","keywords":"Replication (statistics); Cell biology; DNA replication; Computational biology; DNA; Biology; Chemistry; Genetics; Virology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004040998,0.0004019053,0.0003802305,0.0002949313,0.0002370912,0.0005240304,0.0004039707,0.0004401967,0.0009837688],"category_scores_gemma":[0.0002210727,0.0002290422,0.0004221773,0.0001153537,0.0003454364,0.0006181107,0.0002959478,0.0007923737,0.0002732833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000385264,"about_ca_system_score_gemma":0.0002764851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003624995,"about_ca_topic_score_gemma":0.0007608446,"domain_scores_codex":[0.9997414,0.00002756931,0.00002816024,0.00006475938,0.00009938228,0.00003875447],"domain_scores_gemma":[0.9996989,0.00005149527,0.00009685282,0.0000508235,0.00004734471,0.00005462627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001291886,0.00002696335,0.0005714416,0.00005632576,0.00001090387,0.00004310717,0.00001720854,0.0001096001,0.9965284,0.0001220336,0.00001367007,0.002371152],"study_design_scores_gemma":[0.000008177606,0.0003669022,0.00606117,0.000005316806,0.00001640089,0.0001704555,0.00002149792,0.0004455611,0.992137,0.00004344057,0.0007190357,0.000005142111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844959,0.006282742,0.007290113,0.0001353554,0.00003963598,0.00003635998,0.0002563511,0.0001659233,0.00129771],"genre_scores_gemma":[0.9869474,0.002709596,0.006942912,0.00005194274,0.00001931454,0.0000281968,0.0003894859,0.00002309205,0.002888067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009837688,"threshold_uncertainty_score":0.00329107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01300316461328688,"score_gpt":0.250743005376014,"score_spread":0.2377398407627271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}