{"id":"W4384465773","doi":"10.25251/skin.7.supp.220","title":"Efficacy and Safety of Roflumilast Cream 0.15% in Adults and Children Aged ≥6 Years With Mild to Moderate Atopic Dermatitis in Two Phase 3 Trials (INTEGUMENT-1 and INTEGUMENT-2)","year":2023,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Probity Medical Research; Queen's University","funders":"","keywords":"Integument; Atopic dermatitis; Roflumilast; Dermatology; Medicine; Internal medicine; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00174987,0.001009646,0.002264666,0.0002796324,0.0002909731,0.000698717,0.0006639261,0.001246168,0.002892768],"category_scores_gemma":[0.001525483,0.0004874882,0.002128235,0.0002840184,0.0006429814,0.0008286893,0.0003237965,0.002462813,0.0005189738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006661437,"about_ca_system_score_gemma":0.0008046619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001535184,"about_ca_topic_score_gemma":0.004105041,"domain_scores_codex":[0.9992999,0.0003326352,0.00006160153,0.0001217273,0.00006054831,0.0001236885],"domain_scores_gemma":[0.999109,0.0003049396,0.0002147438,0.00005162047,0.00005776445,0.0002619534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8907246,0.01161388,0.009731451,0.001547716,0.001898942,0.0002731034,0.0004049516,0.0004863355,0.01523515,0.0001219933,0.001720246,0.06624155],"study_design_scores_gemma":[0.7051896,0.2282182,0.0598121,0.0001428611,0.001452272,0.0004808314,0.0001617671,0.0004056208,0.001975818,0.0001076124,0.002003217,0.00005002126],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898671,0.007283965,0.0001467275,0.0002808376,0.00009050126,0.0005740439,0.0008183223,0.00004105943,0.0008974861],"genre_scores_gemma":[0.9926442,0.003550939,0.000491962,0.0004903152,0.0001274911,0.0007164378,0.001162113,0.00001499141,0.0008015347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002892768,"threshold_uncertainty_score":0.009677231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0128385366754411,"score_gpt":0.3083747692555938,"score_spread":0.2955362325801527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}