{"id":"W4384493266","doi":"10.15252/emmm.202217248","title":"Nuclear PRMT5 is a biomarker of sensitivity to tamoxifen in ERα+ breast cancer","year":2023,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Direction Générale de l’offre de Soins; Campus France; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; Ligue Contre le Cancer; Strong; Fondation de France; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche; CNIB","keywords":"Biomarker; Breast cancer; Tamoxifen; Cancer; Sensitivity (control systems); Cancer research; Chemistry; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003422803,0.0001623472,0.0002470633,0.0002053114,0.00002390337,0.00000362306,0.00009930298,0.0001575954,0.0001195856],"category_scores_gemma":[0.00007883197,0.0001561322,0.00006811861,0.0007428122,0.00009427916,0.000003085204,0.0001166913,0.00007931478,0.0000242304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004496309,"about_ca_system_score_gemma":0.00007164139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005476939,"about_ca_topic_score_gemma":0.0002011392,"domain_scores_codex":[0.9987187,0.00008752185,0.0002704223,0.0003913094,0.0002647841,0.0002671992],"domain_scores_gemma":[0.9992919,0.0000100431,0.00008233823,0.0003910682,0.0001101589,0.0001145195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001506658,0.00002323658,0.001237489,0.00003254903,0.00006659554,0.00003159072,0.0002813455,0.0006965479,0.9776877,0.00001972689,0.0126262,0.007146313],"study_design_scores_gemma":[0.003015586,0.0004167458,0.3923934,0.00055193,0.0001053176,0.0001100041,0.0002310998,0.004129647,0.5667428,0.0001191699,0.03160242,0.000581871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990183,0.0004248103,0.0003698588,0.008011555,0.0002015077,0.0003013092,0.00005094102,0.00002433063,0.0004326703],"genre_scores_gemma":[0.9981089,0.0001394617,0.0000722535,0.001100195,0.000159718,0.00001936601,0.00008173139,0.00004219998,0.0002761573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.410945,"threshold_uncertainty_score":0.6366885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009182400748619448,"score_gpt":0.278876493551402,"score_spread":0.2696940928027826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}