{"id":"W4384493266","doi":"10.15252/emmm.202217248","title":"Nuclear PRMT5 is a biomarker of sensitivity to tamoxifen in ERα+ breast cancer","year":2023,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Direction Générale de l’offre de Soins; Campus France; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; Ligue Contre le Cancer; Strong; Fondation de France; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche; CNIB","keywords":"Biomarker; Breast cancer; Tamoxifen; Cancer; Sensitivity (control systems); Cancer research; Chemistry; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003863731,0.0002592984,0.0002304386,0.0005678001,0.0001918293,0.0004625897,0.0001718954,0.0003219067,0.001079978],"category_scores_gemma":[0.0007080801,0.0001245286,0.0002104157,0.0002996046,0.0002929078,0.0001928765,0.0002934383,0.0002792687,0.0002399029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002007799,"about_ca_system_score_gemma":0.0001052434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006253538,"about_ca_topic_score_gemma":0.0008249981,"domain_scores_codex":[0.999803,0.00004356815,0.0000194597,0.00005489424,0.00004961964,0.00002949656],"domain_scores_gemma":[0.9997446,0.0000391737,0.0001102083,0.00002981571,0.00003243844,0.00004371902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002028264,0.00007867507,0.5880142,0.0001125151,0.0001310977,0.0004944066,0.0002455322,0.0003481807,0.3895575,0.0001867778,0.0002455638,0.01855722],"study_design_scores_gemma":[0.00001871446,0.0006128992,0.9403751,0.00001740903,0.0001310003,0.002656179,0.0002895427,0.001133839,0.05257913,0.0002069069,0.00196819,0.00001110209],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968034,0.001248816,0.0009434556,0.00006659965,0.00001109732,0.00001195538,0.0001882535,0.00002164956,0.00070479],"genre_scores_gemma":[0.999163,0.0001680744,0.0002213617,0.00001745701,0.000004756748,0.000005503141,0.0001480003,0.000002696235,0.0002691356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001079978,"threshold_uncertainty_score":0.003612876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009182400748619448,"score_gpt":0.278876493551402,"score_spread":0.2696940928027826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}