{"id":"W4384522425","doi":"10.1001/jamaneurol.2023.2169","title":"Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults","year":2023,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute on Aging; Canadian Institutes of Health Research; Avid Radiopharmaceuticals; Genentech; National Institutes of Health; IXICO; H. Lundbeck A/S; Servier; Eisai; Rush University; University of Washington; Pfizer; Biogen; BioClinica; Northern California Institute for Research and Education; Nancy and Buster Alvord Endowment; Siemens Medical Solutions USA; F. Hoffmann-La Roche; University of Pennsylvania; Vanderbilt University; U.S. Department of Defense; Eli Lilly and Company; Kaiser Permanente; University of Southern California; Vanderbilt Memory and Alzheimer's Center; Bristol-Myers Squibb; Novartis Pharmaceuticals Corporation; Alzheimer's Association; Alzheimer's Disease Neuroimaging Initiative; National Center for Advancing Translational Sciences; Meso Scale Diagnostics","keywords":"Apolipoprotein E; Cognition; Psychology; Gerontology; Demography; Medicine; Internal medicine; Disease; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002149236,0.00007817752,0.0002502688,0.0001929031,0.00004072458,0.000004937473,0.00003625748,0.0001058647,0.00005083383],"category_scores_gemma":[0.0002722112,0.00006467046,0.00003365682,0.0002544903,0.0001940223,0.00005694871,0.00004932695,0.0001890712,0.000006435399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003935952,"about_ca_system_score_gemma":0.00003359533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001489922,"about_ca_topic_score_gemma":0.0002056227,"domain_scores_codex":[0.9990613,0.0001159395,0.0001895943,0.000183927,0.0002404036,0.0002088536],"domain_scores_gemma":[0.999263,0.0002687312,0.0001126602,0.0001021415,0.0001892403,0.0000641603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006723615,0.0002130959,0.9856792,0.0001077482,0.0001061065,0.00005661191,0.000461886,0.00000138684,0.006076009,0.00002659718,0.0003015296,0.00629743],"study_design_scores_gemma":[0.005268658,0.001413108,0.9821817,0.00004874454,0.00006615733,0.0000153997,0.0002239448,0.0004936851,0.01010316,0.00005992298,0.00007778455,0.00004767691],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968285,0.00001729637,0.00004374585,0.001334156,0.00001514925,0.0006320851,0.0000574944,0.00003359671,0.001037986],"genre_scores_gemma":[0.9991868,0.00006204708,0.00005121857,0.0002223135,0.00003895031,0.0000632888,0.0001194841,0.00001323571,0.0002427069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006249754,"threshold_uncertainty_score":0.2637185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01120249411631392,"score_gpt":0.273635744775752,"score_spread":0.2624332506594381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}