{"id":"W4384560588","doi":"10.1021/acschemneuro.3c00007","title":"De Novo Design of a β-Helix Tau Protein Scaffold: An Oligomer-Selective Vaccine Immunogen Candidate for Alzheimer’s Disease","year":2023,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome British Columbia; University of British Columbia","funders":"Alberta Prion Research Institute; Canadian Institutes of Health Research; University of British Columbia; Mitacs; Compute Canada","keywords":"Epitope; Immunogen; Helix (gastropod); Oligomer; Chemistry; Tau protein; Linker; Epitope mapping; Linear epitope; Biophysics; Biology; Monoclonal antibody; Alzheimer's disease; Antibody; Computer science; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001899745,0.0003969619,0.000302987,0.0002347017,0.0001465792,0.000315785,0.0002767114,0.0002359783,0.0005433842],"category_scores_gemma":[0.0001929052,0.0001822585,0.0003016649,0.0001613944,0.0001368597,0.0001960716,0.0002768943,0.0003364198,0.0002785231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002914423,"about_ca_system_score_gemma":0.0003756443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003040127,"about_ca_topic_score_gemma":0.0006020281,"domain_scores_codex":[0.9999301,0.00001203863,0.000004542193,0.00001632166,0.00001996085,0.00001707726],"domain_scores_gemma":[0.9999334,0.000006964848,0.00002006411,0.000005224227,0.00001439615,0.00002003914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000209937,0.0002312663,0.00069394,0.0001334416,0.00002888218,0.0002720398,0.00006367247,0.06232901,0.9201159,0.001796699,0.0001930582,0.01393217],"study_design_scores_gemma":[0.0001449766,0.003867103,0.001436165,0.00002809894,0.0001048554,0.000367052,0.0001142423,0.2156708,0.7688981,0.0008906537,0.008442884,0.00003495262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9479674,0.0006214973,0.04859166,0.00007965999,0.00002527829,0.0001531084,0.0001241006,0.0001134213,0.002323874],"genre_scores_gemma":[0.9403742,0.000730758,0.05691799,0.00004447277,0.0000064112,0.0001160467,0.0002652537,0.00002664108,0.00151834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005433842,"threshold_uncertainty_score":0.002114534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01815118148719719,"score_gpt":0.2804909732049712,"score_spread":0.262339791717774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}