{"id":"W4384560588","doi":"10.1021/acschemneuro.3c00007","title":"De Novo Design of a β-Helix Tau Protein Scaffold: An Oligomer-Selective Vaccine Immunogen Candidate for Alzheimer’s Disease","year":2023,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome British Columbia; University of British Columbia","funders":"Alberta Prion Research Institute; Canadian Institutes of Health Research; University of British Columbia; Mitacs; Compute Canada","keywords":"Epitope; Immunogen; Helix (gastropod); Oligomer; Chemistry; Tau protein; Linker; Epitope mapping; Linear epitope; Biophysics; Biology; Monoclonal antibody; Alzheimer's disease; Antibody; Computer science; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001948907,0.000170687,0.0001585087,0.00005011524,0.00009163499,0.00002640855,0.0005010362,0.00009790173,0.000001328578],"category_scores_gemma":[0.0004004149,0.0001577599,0.00006797108,0.0003796467,0.0001323302,0.00001378606,0.0001728984,0.00007122065,0.000001204801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001343731,"about_ca_system_score_gemma":0.0002246866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001712687,"about_ca_topic_score_gemma":0.00000186779,"domain_scores_codex":[0.9986408,0.00004516886,0.0002011836,0.0005200866,0.0001613935,0.0004314073],"domain_scores_gemma":[0.9991856,0.00002115238,0.00009181628,0.0004060605,0.00009678862,0.0001985822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003976523,0.00004295073,0.0002091135,0.00001542856,0.000008658132,0.00000556343,0.00001943913,0.0002971128,0.998041,0.00007419442,0.0001373917,0.0007514894],"study_design_scores_gemma":[0.0004676301,0.0003204059,0.001291375,0.00001005107,0.00002968451,0.00001120309,0.000005375715,0.003007347,0.9932492,0.001040042,0.0003776191,0.0001900868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987179,0.0001679488,0.01155223,0.000128534,0.00006014333,0.0007413302,0.0001235591,0.0000359767,0.00001124213],"genre_scores_gemma":[0.9972096,0.00004118058,0.001948035,0.0003520413,0.00007900783,0.0001890438,0.0001004793,0.00002595653,0.00005464302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01003058,"threshold_uncertainty_score":0.6433261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01815118148719719,"score_gpt":0.2804909732049712,"score_spread":0.262339791717774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}