{"id":"W4384563170","doi":"10.1016/j.ejps.2023.106529","title":"Design, synthesis and biological evaluation of a novel bioactive indane scaffold 2-(diphenylmethylene)c-2,3-dihydro-1H-inden-1-one with potential anticancer activity","year":2023,"lang":"en","type":"article","venue":"European Journal of Pharmaceutical Sciences","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Trinity College Dublin","keywords":"Chemistry; Cytotoxicity; SKBR3; A549 cell; Stereochemistry; DU145; Moiety; In vitro; Biochemistry; Cancer cell; Biology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001168586,0.0002644685,0.0002107538,0.0001980909,0.0001202904,0.000212257,0.0002587464,0.0002035568,0.0009779205],"category_scores_gemma":[0.00008304121,0.00009010941,0.0001577064,0.0001539248,0.0001402109,0.0002101434,0.0001612409,0.0002288601,0.0002914756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001772881,"about_ca_system_score_gemma":0.000190763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002687238,"about_ca_topic_score_gemma":0.0005176569,"domain_scores_codex":[0.9999493,0.00000733232,0.00000334373,0.0000118404,0.00001463701,0.00001346319],"domain_scores_gemma":[0.9999604,0.00000449878,0.00001160775,0.000003578281,0.000007358833,0.00001255995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009076624,0.00009694643,0.0001343589,0.0001268992,0.00000896121,0.0001470719,0.00003061516,0.0007980131,0.9934462,0.0002268824,0.0000346907,0.004858575],"study_design_scores_gemma":[0.0000602997,0.002856811,0.002113354,0.00001157698,0.00004143329,0.0003664629,0.00003613314,0.001518918,0.9864825,0.00007653605,0.006419157,0.00001687706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98875,0.0027097,0.005766048,0.0000939366,0.00001677024,0.0001427413,0.0002861296,0.0000405439,0.002194258],"genre_scores_gemma":[0.9893941,0.001712635,0.006526716,0.00004057952,0.00001087516,0.00005212034,0.0003579049,0.000006966698,0.001898139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009779205,"threshold_uncertainty_score":0.00327152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4405693627650637,"score_gpt":0.4689393797120578,"score_spread":0.02837001694699415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}