{"id":"W4384563648","doi":"10.1016/j.nucmedbio.2023.108367","title":"Relative Biological Effectiveness (RBE) of [64Cu]Cu and [177Lu]Lu-NOTA-panitumumab F (ab')2 radioimmunotherapeutic agents vs. γ-radiation for decreasing the clonogenic survival in vitro of human pancreatic ductal adenocarcinoma (PDAC) cells","year":2023,"lang":"en","type":"article","venue":"Nuclear Medicine and Biology","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"","keywords":"Clonogenic assay; Panitumumab; Cancer research; Radioimmunotherapy; In vitro; Adenocarcinoma; Cell culture; Chemistry; Medicine; Molecular biology; Nuclear medicine; Internal medicine; Cancer; Biology; Immunology; Colorectal cancer; Monoclonal antibody; Biochemistry; Antibody; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007786427,0.0005163613,0.00063927,0.0004257734,0.0001578874,0.0003822646,0.0004265692,0.0006438957,0.001881741],"category_scores_gemma":[0.0007610103,0.0003000637,0.0003303684,0.0003392651,0.0003321321,0.0004386446,0.0001935203,0.0006261733,0.0003602317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003152238,"about_ca_system_score_gemma":0.0003655611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001167294,"about_ca_topic_score_gemma":0.001122484,"domain_scores_codex":[0.9994892,0.0002304816,0.00004210532,0.00006799179,0.00008719843,0.00008308385],"domain_scores_gemma":[0.9995806,0.0002170533,0.00006123741,0.00003960283,0.00005109137,0.00005042332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009881841,0.0006150415,0.0008653009,0.0005373937,0.0001682989,0.0001231727,0.000187278,0.00175205,0.9620712,0.0004834631,0.0003691025,0.02294589],"study_design_scores_gemma":[0.0002680335,0.01443519,0.005791823,0.00003023073,0.0003657076,0.000360663,0.0001149353,0.001783498,0.9733859,0.00007158983,0.003365943,0.00002634647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972764,0.02077588,0.001432626,0.000168356,0.0001630994,0.00004438568,0.0002461213,0.00009140588,0.004314123],"genre_scores_gemma":[0.9920414,0.003906568,0.0009553865,0.00006979163,0.00004115888,0.0000507881,0.0003062365,0.00002500444,0.002603601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001881741,"threshold_uncertainty_score":0.006295085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1011543287388719,"score_gpt":0.3703808913925409,"score_spread":0.2692265626536691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}