{"id":"W4384571557","doi":"10.2139/ssrn.4506566","title":"Paediatric Meningitis in the Conjugate Vaccine Era and Development of a Novel Clinical Decision Model to Predict Bacterial Aetiology in 3,002 Children with Suspected Meningitis","year":2023,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; Institute of Infection and Immunity","funders":"","keywords":"Bacterial meningitis; Meningitis; Etiology; Medicine; Intensive care medicine; Conjugate vaccine; Pediatrics; Immunology; Internal medicine; Immunization; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004094434,0.000789583,0.001393208,0.0008202411,0.0003789038,0.002065033,0.0007088134,0.001297045,0.001684571],"category_scores_gemma":[0.01173869,0.0004021675,0.0007674222,0.0004807899,0.0003078279,0.0008052993,0.0007628759,0.001468139,0.0002484349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001210535,"about_ca_system_score_gemma":0.002470163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01261434,"about_ca_topic_score_gemma":0.005769878,"domain_scores_codex":[0.9990877,0.0004726357,0.000088179,0.0001614948,0.00007362679,0.0001164992],"domain_scores_gemma":[0.9906206,0.008024826,0.0004167117,0.00009705192,0.0003697271,0.0004709831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.003224291,0.0008731424,0.2266518,0.0001100186,0.0003692238,0.0007115793,0.0002470424,0.7134015,0.0007064836,0.003094037,0.002569613,0.04804128],"study_design_scores_gemma":[0.00003633865,0.0001032754,0.00325156,0.00001117422,0.00003214907,0.00006172064,0.00004003818,0.9951747,0.0001424765,0.001013567,0.0001251793,0.000007900905],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9311439,0.0006614845,0.06282707,0.002342656,0.00011737,0.0001550623,0.001273051,0.0001519766,0.001327527],"genre_scores_gemma":[0.9816973,0.0002212042,0.01629523,0.000150783,0.00007941402,0.0001109419,0.0009522964,0.00001257721,0.0004802904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01261434,"threshold_uncertainty_score":0.02508181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02271884718992768,"score_gpt":0.2833759395668518,"score_spread":0.2606570923769241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}