{"id":"W4384627184","doi":"10.1007/s40273-023-01294-3","title":"Cost-Effectiveness of Hydroxyurea for Sickle Cell Anemia in a Low-Income African Setting: A Model-Based Evaluation of Two Dosing Regimens","year":2023,"lang":"en","type":"article","venue":"PharmacoEconomics","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Haukeland Universitetssjukehus; Norges Forskningsråd; Universitetet i Bergen","keywords":"Medicine; Cost effectiveness; Dosing; Regimen; Economic evaluation; Disease burden; Quality-adjusted life year; Health economics; Pediatrics; Sickle cell anemia; Anemia; Public health; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002056116,0.0001417415,0.000388685,0.0002779657,0.00003175226,0.000004929807,0.00008111136,0.00007992172,0.00001638973],"category_scores_gemma":[0.00006620272,0.000146754,0.0001270512,0.0002721351,0.000059217,0.00006013797,0.00002485467,0.0001420463,0.000005236629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002873074,"about_ca_system_score_gemma":0.0004574002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005603943,"about_ca_topic_score_gemma":0.000005340198,"domain_scores_codex":[0.998814,0.0001162851,0.0004316214,0.0002442877,0.0001360008,0.0002578223],"domain_scores_gemma":[0.9990299,0.0003288491,0.0002291156,0.0001836807,0.0001465249,0.00008196232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0008819419,0.0002398621,0.002958867,0.001473444,0.00004372778,0.000002407302,0.0005610603,0.894406,0.09625207,0.00004142355,0.00007831377,0.003060877],"study_design_scores_gemma":[0.01208538,0.00008251928,0.0004005838,0.0002407664,0.0002308961,9.631252e-7,0.0001653016,0.8111753,0.175045,0.0004268023,0.00003524922,0.0001112165],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951196,0.0001492269,0.001117611,0.0002001137,0.0001295177,0.002074512,0.00006124204,0.00003689451,0.001111315],"genre_scores_gemma":[0.999104,0.00004850843,0.0004096335,0.00007809649,0.00002519327,0.0001868215,0.00009522559,0.00003494636,0.00001757518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08323064,"threshold_uncertainty_score":0.5984454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0418944135521632,"score_gpt":0.3783064997852639,"score_spread":0.3364120862331007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}